Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells
文献类型：期刊论文
| 作者 | Yu, M; Cai, L; Liang, M; Huang, YL; Gao, H; Lu, SD; Fei, J; Huang, F |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 65期号:3页码:236-244 |
| 关键词 | NRSF REST4 MPP(+) SH-SY5Y cell Parkinson's disease |
| 通讯作者 | Huang, F (reprint author), Fudan Univ, Natl Key Lab Med Neurobiol, Shanghai Med Coll, Shanghai 200032, Peoples R China., |
| 英文摘要 | Neuron-restrictive silencer factor (NRSF)/neuronal repressor element-1 silencing transcription factor (REST) and its neuron-specific truncated form REST4 participates in the pathological processes of nervous system diseases, such as global ischemia, epilepsy, Huntington disease and so on. In this paper, we investigated the changes of NRSF and REST4 in a cellular model of Parkinson's disease (PD). Our results showed that neurotoxin 1-methyl-4-phenyl-pyridinium ion (MPP(+)) treatment triggered the mRNA and protein expression of NRSF and REST4, and caused both NRSF and REST4 proteins relocalized between the nucleus and cytoplasm in human dopaminergic SH-SY5Y cells. Redistribution of NRSF and REST4 derepressed the expression of target genes at late time points Furthermore, alteration of NRSF and REST4 expression by overexpression or RNAi techniques elicited deleterious effects on cell viability of SH-SY5Y treated with toxic MPP(+). (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | RESTRICTIVE SILENCER FACTOR ; GENE-EXPRESSION ; NEURONAL GENES ; TARGET GENES ; TRANSCRIPTION FACTOR ; IN-VIVO ; REPRESSOR ; REST4 ; DISEASE ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271131100004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1157]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yu, M,Cai, L,Liang, M,et al. Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells[J]. NEUROSCIENCE RESEARCH,2009,65(3):236-244. |
| APA | Yu, M.,Cai, L.,Liang, M.,Huang, YL.,Gao, H.,...&Huang, F.(2009).Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells.NEUROSCIENCE RESEARCH,65(3),236-244. |
| MLA | Yu, M,et al."Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells".NEUROSCIENCE RESEARCH 65.3(2009):236-244. |
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