MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells
文献类型：期刊论文
| 作者 | Huang, B; Li, W; Zhao, B; Xia, CA; Liang, RQ; Ruan, KC; Jing, NH; Jin, YX |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2009 |
| 卷号 | 41期号:3页码:231-236 |
| 关键词 | microRNA embryonic carcinoma P19 cell neural stem cells neural differentiation |
| 通讯作者 | Jin, YX (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,yxjin@sibs.ac.cn |
| 英文摘要 | MicroRNAs (or miRNAs) are small non-coding RNAs (21-25 nucleotides) that are involved in a wide range of activities related to the development and differentiation of cells. Comparison of the miRNA expression profiles of mouse P19 embryonic carcinoma cells with those of differentiated neural stem cells showed that the expression level of 65 miRNAs changed (2-fold) after differentiation. MiR-124a was dramatically up-regulated (more than 20-fold) while miRNAs of the miR-302 family and those in the miR-290-295 cluster were strongly down-regulated. Further analysis revealed that some important factors such as Oct4 and Sox2 appeared to be involved in the regulation of these miRNAs. These results may contribute to a better understanding of miRNA-regulated neural differentiation in early mouse embryos. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | STEM-CELLS ; NEURONAL DIFFERENTIATION ; IDENTIFICATION ; NETWORK ; TARGETS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263943400007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1162]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, B,Li, W,Zhao, B,et al. MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41(3):231-236. |
| APA | Huang, B.,Li, W.,Zhao, B.,Xia, CA.,Liang, RQ.,...&Jin, YX.(2009).MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41(3),231-236. |
| MLA | Huang, B,et al."MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41.3(2009):231-236. |
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