c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2
文献类型：期刊论文
| 作者 | Wang, XM; Zhang, YF; Xiao, G; Gao, X; Liu, XL |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 19期号:3页码:340-347 |
| 关键词 | c-Fos Bcl-2 survival thymocyte development positive selection |
| 通讯作者 | Liu, XL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,liux@sibs.ac.cn |
| 英文摘要 | T cells are derived from progenitor thymocytes, of which only a minority receive the appropriate TCR signal, undergo positive selection and mature. Owing to the very short lifespan of thymocytes, the prerequisite for positive selection is survival. TCR signal-induced Bcl-2 expression is believed to play a dominant role in the survival of positively selecting thymocytes, but how Bcl-2 is directly regulated is unknown. Here we report that the immediate early gene (IEG) c-Fos can stimulate the expression of Bcl-2, depending on a specific AP-1-binding site in the Bcl-2 promoter. In c-Fos transgenic (Fos-Tg) mice, c-Fos binds to this site and promotes the expression of Bcl-2. As a result, Fos-Tg thymocytes exhibited enhanced survival, and more mature single-positive (SP) thymocytes were generated, even on a unique TCR background. The TCR repertoire remained normal in Fos-Tg mice. Our results identified c-Fos as the mediator of the stimulatory effect of TCR signaling on Bcl-2 expression. Therefore, c-Fos, as an IEG, because of its early response ability, can quickly rescue the survival of short-lived thymocytes during positive selection. Our results provide novel insight into the mechanism regulating the survival of positively selecting thymocytes. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | IMMEDIATE-EARLY GENE ; T-CELL RECEPTOR ; CD4(+)CD8(+) THYMOCYTES ; NEGATIVE SELECTION ; THYMIC SELECTION ; TRANSCRIPTION ; APOPTOSIS ; EXPRESSION ; PROTEIN ; AP-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000265700000009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1163]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XM,Zhang, YF,Xiao, G,et al. c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2[J]. CELL RESEARCH,2009,19(3):340-347. |
| APA | Wang, XM,Zhang, YF,Xiao, G,Gao, X,&Liu, XL.(2009).c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2.CELL RESEARCH,19(3),340-347. |
| MLA | Wang, XM,et al."c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2".CELL RESEARCH 19.3(2009):340-347. |
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