Improvement of Morphine-Mediated Analgesia by Inhibition of beta-Arrestin 2 Expression in Mice Periaqueductal Gray Matter
文献类型：期刊论文
| 作者 | Li, YT; Liu, X; Liu, C; Kang, JH; Yang, JY; Pei, G; Wu, CF |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2009 |
| 卷号 | 10期号:3页码:954-963 |
| 关键词 | beta-Arrestin 2 Lentivirus Periaqueductal gray Analgesia Morphine |
| 通讯作者 | Wu, CF (reprint author), Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China.,genggeng800816@yahoo.com ; xingliu@fudan.edu.cn ; lonelyrunner27@yahoo.com.cn ; jhkang@sibs.ac.cn ; yangjingyu2006@gmail.com ; gpei@sibs.ac.cn ; wucf@syphu.edu.cn |
| 英文摘要 | Morphine is a well-known mu-opioid receptor (MOR) agonist and an efficient analgesic, but its long-term use inevitably leads to drug addiction and tolerance. Here, we show that specific inhibition of mu-arrestin2 with its siRNA lentivirus microinjected in mice periaqueductal gray matter (PAG) significantly improved both acute and chronic morphine analgesia and delayed the tolerance in the hotplate test. The specific effect of beta-arrestin2 was proven by overexpression or knockdown of its homology beta-arrestin1 in PAG, which showed no significant effects on morphine analgesia. These findings suggest that specific siRNA targeting beta-arrestin2 may constitute a new approach to morphine therapy and other MOR agonist-mediated analgesia and tolerance. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 关键词[WOS] | COUPLED RECEPTOR KINASES ; MU-OPIOID RECEPTORS ; KNOCK-OUT MICE ; RAT-BRAIN ; BETA-ARRESTIN-2 ; TOLERANCE ; DESENSITIZATION ; GENE ; EFFICACY ; LIGANDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264565300014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1165]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, YT,Liu, X,Liu, C,et al. Improvement of Morphine-Mediated Analgesia by Inhibition of beta-Arrestin 2 Expression in Mice Periaqueductal Gray Matter[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2009,10(3):954-963. |
| APA | Li, YT.,Liu, X.,Liu, C.,Kang, JH.,Yang, JY.,...&Wu, CF.(2009).Improvement of Morphine-Mediated Analgesia by Inhibition of beta-Arrestin 2 Expression in Mice Periaqueductal Gray Matter.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,10(3),954-963. |
| MLA | Li, YT,et al."Improvement of Morphine-Mediated Analgesia by Inhibition of beta-Arrestin 2 Expression in Mice Periaqueductal Gray Matter".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 10.3(2009):954-963. |
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