Regulation of mammalian pre-mRNA splicing
文献类型：期刊论文
| 作者 | Hui, JY |
| 刊名 | SCIENCE IN CHINA SERIES C-LIFE SCIENCES
 |
| 出版日期 | 2009 |
| 卷号 | 52期号:3页码:253-260 |
| 关键词 | pre-mRNA splicing alternative splicing splicing regulation signal transduction microRNA |
| 通讯作者 | Hui, JY (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,jyhui@sibs.ac.cn |
| 英文摘要 | In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 类目[WOS] | Biology |
| 关键词[WOS] | DOMINANT RETINITIS-PIGMENTOSA ; SPINAL MUSCULAR-ATROPHY ; 2 DIFFERENT CHROMOSOMES ; GENOME-WIDE SURVEY ; PROTEIN-KINASE-C ; MYOTONIC-DYSTROPHY ; SIGNAL-TRANSDUCTION ; HUMAN TRANSCRIPTOME ; PROTEOMIC ANALYSIS ; GLOBAL ANALYSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264329900008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1169]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hui, JY. Regulation of mammalian pre-mRNA splicing[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2009,52(3):253-260. |
| APA | Hui, JY.(2009).Regulation of mammalian pre-mRNA splicing.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,52(3),253-260. |
| MLA | Hui, JY."Regulation of mammalian pre-mRNA splicing".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 52.3(2009):253-260. |
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