RIM-BP3 is a manchette-associated protein essential for spermiogenesis
文献类型：期刊论文
| 作者 | Zhou, J; Du, YR; Qin, WH; Hu, YG; Huang, YN; Bao, L; Han, DS; Mansouri, A; Xu, GL |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2009 |
| 卷号 | 136期号:3页码:373-382 |
| 关键词 | RIM-BP3 (Rimbp3) Hook1 Spermatid manchette Spermiogenesis Mouse |
| 通讯作者 | Xu, GL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,glxu@sibs.ac.cn |
| 英文摘要 | During spermiogenesis, round spermatids are converted into motile sperm in mammals. The mechanisms responsible for sperm morphogenesis are poorly understood. We have characterized a novel protein, RIM-BP3, with a specialized function in spermatid development in mice. The RIM-BP3 protein is associated with the manchette, a transient microtubular structure believed to be important for morphogenesis during spermiogenesis. Targeted deletion of the RIM-BP3 gene resulted in male infertility owing to abnormal sperm heads, which are characterized by a deformed nucleus and a detached acrosome. Consistent with its role in morphogenesis, the RIM-BP3 protein physically associates with Hook1, a known manchette-bound protein required for sperm head morphogenesis. Interestingly, RIM-BP3 does not interact with the truncated Hook1 protein characterized in azh ( abnormal spermatozoon head) mutant mice. Moreover, RIM-BP3 and Hook1 mutant mice display several common abnormalities, in particular with regard to the ectopic positioning of the manchette within the spermatid, a presumed cause of sperm head deformities. These observations suggest an essential role for RIM-BP3 in manchette development and function through its interaction with Hook1. As the occurrence of deformed spermatids is one of the common abnormalities leading to malfunctional sperm, identification of RIM-BP3 might provide insight into the molecular cue underlying causes of male infertility in humans. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | SPERMATOGENIC CELLS ; MALE-INFERTILITY ; MICE LACKING ; DECAPITATED SPERMATOZOA ; DNA METHYLTRANSFERASES ; ACROSOME FORMATION ; ESCHERICHIA-COLI ; DEFICIENT MICE ; MUTANT MOUSE ; ICF SYNDROME |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262409500004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1170]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, J,Du, YR,Qin, WH,et al. RIM-BP3 is a manchette-associated protein essential for spermiogenesis[J]. DEVELOPMENT,2009,136(3):373-382. |
| APA | Zhou, J.,Du, YR.,Qin, WH.,Hu, YG.,Huang, YN.,...&Xu, GL.(2009).RIM-BP3 is a manchette-associated protein essential for spermiogenesis.DEVELOPMENT,136(3),373-382. |
| MLA | Zhou, J,et al."RIM-BP3 is a manchette-associated protein essential for spermiogenesis".DEVELOPMENT 136.3(2009):373-382. |
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