The Important Role of Three Auxiliary Factors of Mammalian Aminoacyl-tRNA Synthetase Complex in The Cellular Signaling Network
文献类型：期刊论文
| 作者 | He, R; Wang, ED |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2009 |
| 卷号 | 36期号:4页码:398-402 |
| 关键词 | mammalian aminoacyl-tRNA synthetase auxiliary factor DNA damage repair signaling network |
| 通讯作者 | Wang, ED (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,edwang@sibs.ac.cn |
| 英文摘要 | Aminoacyl-tRNA synthetase catalyzing the first reaction of protein biosynthesis. In mammalian cells, eight aminoacyl-tRNA synthetases (aaRSs) and three auxiliary protein factors form a macromolecular aminoacyl-tRNA synthetases complex (aaRS complex). The three nonsynthetase protein factors, namely, p43, p38, and p 18 were found to be involved in many other important life activities besides their roles in the complex. The auxiliary factor p43 was the precursor of endothelial monocyte activating polypeptide 11 (EMAP U), which involved in angiogenesis and apoptosis. The auxiliary factor p38 was crucial for the development of lung, and its abnormal accumulation in neuron would be related to the Parkinson's disease. The auxiliary factor p38 and p 18 could promote the repair of DNA damage via different pathways in a highly organized way. All these breakthroughs enhance our understanding about the interaction between the aaRS complex and the macromolecular signaling network and promote the studies on this field. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | PROTEIN ; TRANSLATION ; APOPTOSIS ; P43 ; ANGIOGENESIS ; CYTOKINE ; WORKING ; P38 ; P53 |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000265411600002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1181]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | He, R,Wang, ED. The Important Role of Three Auxiliary Factors of Mammalian Aminoacyl-tRNA Synthetase Complex in The Cellular Signaling Network[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2009,36(4):398-402. |
| APA | He, R,&Wang, ED.(2009).The Important Role of Three Auxiliary Factors of Mammalian Aminoacyl-tRNA Synthetase Complex in The Cellular Signaling Network.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,36(4),398-402. |
| MLA | He, R,et al."The Important Role of Three Auxiliary Factors of Mammalian Aminoacyl-tRNA Synthetase Complex in The Cellular Signaling Network".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 36.4(2009):398-402. |
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