EBV-Induced Human CD8(+) NKT Cells Synergise CD4(+) NKT Cells Suppressing EBV-Associated Tumours upon Induction of Th1-Bias
文献类型：期刊论文
| 作者 | Xiao, W; Li, L; Zhou, R; Xiao, RJ; Wang, YJ; Ji, X; Wu, MJ; Wang, L; Huang, W; Zheng, XL |
| 刊名 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 6期号:5页码:367-379 |
| 关键词 | CD8(+) NKT cells EBV human-thymus-SCID chimaeras IFN-gamma |
| 通讯作者 | He, YL (reprint author), Wuhan Univ, Lab Allergy & Clin Immunol, Inst Allergy & Immune Related Dis, Med Res Ctr,Sch Med, Dong Hu Rd 185, Wuhan 430071, Peoples R China.,jinquan_tan@whu.edu.cn ; flying_bird2004@126.com |
| 英文摘要 | CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or Th cytokine secretion. Circulating mDC1 cells from patients with EBV-associated malignancies impair the production of IFN-gamma by CD8(+) NKT cells. In this study, we have established a human-thymus-SCID chimaera model to further investigate the underlying mechanism of EBV-induced CD8(+) NKT cells in suppressing EBV-associated malignancies. In the human-thymus-SCID chimera, EBV-induced CD8(+) NKT cells suppress EBV-associated malignancies in a manner dependent on the Th1-bias response and syngeneic CD3(+) T cells. However, adoptive transfer with CD4(+) NKT cells alone inhibits T cell immunity. Interestingly, CD4(+) NKT cells themselves secrete high levels of IL-2, enhancing the persistence of adoptively transferred CD8(+) NKT cells and T cells, thereby leading to a more pronounced T cell anti-tumour response in chimaeras co-transferred with CD4(+) and CD8(+) NKT cells. Thus, immune reconstitution with EBV-induced CD4(+) and CD8(+) NKT cells synergistically enhances T cell tumour immunity, providing a potential prophylactic and therapeutic treatment for EBV-associated malignancies. Cellular & Molecular Immunology. 2009;6(5):367-379. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | EPSTEIN-BARR-VIRUS ; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE ; LIGAND ALPHA-GALACTOSYLCERAMIDE ; CYTOTOXIC T-CELLS ; DENDRITIC CELLS ; ACTIVATION ; INFECTION ; RECOGNITION ; EXPRESSION ; THYMOCYTES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274324100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1188]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, W,Li, L,Zhou, R,et al. EBV-Induced Human CD8(+) NKT Cells Synergise CD4(+) NKT Cells Suppressing EBV-Associated Tumours upon Induction of Th1-Bias[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(5):367-379. |
| APA | Xiao, W.,Li, L.,Zhou, R.,Xiao, RJ.,Wang, YJ.,...&He, YL.(2009).EBV-Induced Human CD8(+) NKT Cells Synergise CD4(+) NKT Cells Suppressing EBV-Associated Tumours upon Induction of Th1-Bias.CELLULAR & MOLECULAR IMMUNOLOGY,6(5),367-379. |
| MLA | Xiao, W,et al."EBV-Induced Human CD8(+) NKT Cells Synergise CD4(+) NKT Cells Suppressing EBV-Associated Tumours upon Induction of Th1-Bias".CELLULAR & MOLECULAR IMMUNOLOGY 6.5(2009):367-379. |
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