New conotoxins define the novel I(3)-superfamily
文献类型：期刊论文
| 作者 | Yuan, DD; Liu, L; Shao, XX; Peng, C; Chi, CW; Guo, ZY |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:5页码:861-865 |
| 关键词 | Conotoxin I-superfamily cDNA cloning |
| 通讯作者 | Chi, CW (reprint author), Tongji Univ, Coll Life Sci & Technol, Inst Prot Res, 1239 Siping Rd, Shanghai 200092, Peoples R China.,zwqi@sibs.ac.cn ; zhan-yun.guo@mail.tongji.edu.cn |
| 英文摘要 | We purified two novel conotaxins, designated as ca11a and ca11b, from the venom of Conus caracretisticus. Based on the amino acid sequence of mature ca11a, we cloned its full-length cDNA. Based on the signal peptide of ca11a, several ca11a-like conotoxins were cloned from C caracteristicus and C pulicarius. These novel conotoxins have an I-superfamily cysteine pattern but with a novel signal peptide sequence, suggesting they belong to a new branch of I-superfamily, designated as I(3)-superfamily. Additionally, two O-superfamily conotoxins were also cloned based on the signal peptide of ca11a, suggesting a possible evolutionary relationship between O- and I-superfamilies. (C) 2009 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | 3-DIMENSIONAL SOLUTION STRUCTURE ; UNIQUE CYSTEINE PATTERN ; CONUS-LITTERATUS ; RICH SOURCE ; SUPERFAMILY ; CHANNEL ; PEPTIDE ; IDENTIFICATION ; CLONING ; VENOMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266369900006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1197]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yuan, DD,Liu, L,Shao, XX,et al. New conotoxins define the novel I(3)-superfamily[J]. PEPTIDES,2009,30(5):861-865. |
| APA | Yuan, DD,Liu, L,Shao, XX,Peng, C,Chi, CW,&Guo, ZY.(2009).New conotoxins define the novel I(3)-superfamily.PEPTIDES,30(5),861-865. |
| MLA | Yuan, DD,et al."New conotoxins define the novel I(3)-superfamily".PEPTIDES 30.5(2009):861-865. |
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