Highly sensitive detection of melamine based on reversed phase liquid chromatography mass spectrometry
文献类型：期刊论文
| 作者 | Wu, QQ; Fan, KX; Sha, W; Ruan, HQ; Zeng, R; Shieh, CH |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2009 |
| 卷号 | 54期号:5页码:732-737 |
| 关键词 | reversed phase liquid chromatography mass spectrometry melamine multiple reaction monitoring ion pair |
| 通讯作者 | Zeng, R (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.,zr@sibs.ac.cn ; jhxie@sibs.ac.cn |
| 英文摘要 | In this work, we developed a highly sensitive method to detect melamine based on reversed phase liquid chromatography mass spectrometry. A mass spectrometry compatible ion pair, heptafluorobutyric acid(HFBA), was used to separate melamine by reversed phase liquid chromatography prior to electrospray mass spectrometry. The incorporation of isotope internal standard and multiple reaction monitoring improved the accuracy and linearity of quantification. Based on this strategy, the method limit of quantification was 0.1 ng/g. The limits of quantification were 8 ng/g for liquid milk and 15 ng/g for dry milk powder. This method provided a reproducible and stable approach to sensitive detection and quantification of melamine. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | CYROMAZINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263787900005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1199]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, QQ,Fan, KX,Sha, W,et al. Highly sensitive detection of melamine based on reversed phase liquid chromatography mass spectrometry[J]. CHINESE SCIENCE BULLETIN,2009,54(5):732-737. |
| APA | Wu, QQ,Fan, KX,Sha, W,Ruan, HQ,Zeng, R,&Shieh, CH.(2009).Highly sensitive detection of melamine based on reversed phase liquid chromatography mass spectrometry.CHINESE SCIENCE BULLETIN,54(5),732-737. |
| MLA | Wu, QQ,et al."Highly sensitive detection of melamine based on reversed phase liquid chromatography mass spectrometry".CHINESE SCIENCE BULLETIN 54.5(2009):732-737. |
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