Sequences near both termini of the C/EBP beta mRNA 3' untranslated region are important for its tumor suppression activity
文献类型：期刊论文
| 作者 | Wang, HZ; Wang, Y; Sun, L; Liu, DG |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2009 |
| 卷号 | 41期号:6页码:456-463 |
| 关键词 | C EBP beta 3' UTR tumor suppression deletion |
| 通讯作者 | Liu, DG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,dgliu@sibs.ac.cn |
| 英文摘要 | The 3' untranslated region (3' UTR) of eukaryotic mRNA is an important regulation element that affects not only mRNA translation, but also cell growth. We had found that the 3' UTR of CCAAT-enhancer-binding protein beta (C/EBP beta) mRNA had tumor suppression activity. Herein, we reported that deletion of two short sequences at both termini of the C/EBP beta 3' UTR reduced the tumor suppression activity of this 3' UTR, as demonstrated by reduced cell growth, colony formation ability, and tumorigenicity in nude mice. It is noteworthy that the only deletion of a single such sequence was enough for the reduction of tumor suppression effect, and the reducing effect of deletion of the sequence near 3' terminus was stronger. Therefore, specific short sequences in the C/EBP beta 3' UTR are crucial for the tumor suppression activity of C/EBP beta. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | BREAST-CANCER ; CELL-LINES ; NUDE-MICE ; GROWTH ; PROHIBITIN ; REVERSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266703900003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1205]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, HZ,Wang, Y,Sun, L,et al. Sequences near both termini of the C/EBP beta mRNA 3' untranslated region are important for its tumor suppression activity[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41(6):456-463. |
| APA | Wang, HZ,Wang, Y,Sun, L,&Liu, DG.(2009).Sequences near both termini of the C/EBP beta mRNA 3' untranslated region are important for its tumor suppression activity.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41(6),456-463. |
| MLA | Wang, HZ,et al."Sequences near both termini of the C/EBP beta mRNA 3' untranslated region are important for its tumor suppression activity".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41.6(2009):456-463. |
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