Caulis Sinomenii Extracts Activate DA/NE Transporter and Inhibit 5HT Transporter
文献类型：期刊论文
| 作者 | Zhao, G; Bi, C; Qin, GW; Guo, LH |
| 刊名 | EXPERIMENTAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2009 |
| 卷号 | 234期号:8页码:976-985 |
| 关键词 | Caulis Sinomenii dopamine norepinephrine serotonin reuptake modulator transporter |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lhguo@sibs.ac.cn |
| 英文摘要 | Caulis Sinomenii (QFT) has analgesic, sedative, and anxiolytic-like actions, and is proven effective for improving drug dependence that is known to be associated with abnormal monoaminergic transmission. We assessed whether QFT would be biologically active in functionally regulating monoamine transporters using CHO cells expressing dopamine transporter (DAT), norepinephrine transporter (NET), or serotonin transporter (SERT) (i.e. D8, N1, or S6 cells, respectively). Here, we showed that its primary extracts, such as QA, QC, QE, QD, and QB (QFT ethanol, chloroform, ethyl acetate, alkaloid-free chloroform, and alkaloid-containing chloroform extract, respectively), and secondary extracts, such as QE-2, -3, -5, -7, QD-1, -2, -3, -4, -5, and QB-1, -2, -3, -4, -5 (fractioned from QE, QD, and QB, respectively), in differing degrees, either increased DA/NE uptake by corresponding D8/N1 cells or decreased 5HT uptake by S6 cells; wherein, QE-2, QD-3, and QE-7 were potent DAME uptake activators while both QE-7 and QB-5 were potent 5HT uptake inhibitors. Furthermore, the enhancement of DA/NE uptake was dependent of DAT/NET activity, and the inhibition of 5HT uptake was typical of competition. Thus, QFT extracts, especially QE-2 and QE-7 (both with stronger potencies), are novel monoamine transporter modulators functioning as DAT/NET activators and/or SERT inhibitors, and would likely improve neuropsychological disorders through regulating monoamine transporters. Exp Biol Med 234:976-985, 2009 |
| 学科主题 | Research & Experimental Medicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 关键词[WOS] | MONOAMINE TRANSPORTERS ; DOPAMINE TRANSPORTER ; SEROTONIN TRANSPORTER ; RAT MODEL ; MECHANISMS ; ADDICTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268567300012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1226]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, G,Bi, C,Qin, GW,et al. Caulis Sinomenii Extracts Activate DA/NE Transporter and Inhibit 5HT Transporter[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2009,234(8):976-985. |
| APA | Zhao, G,Bi, C,Qin, GW,&Guo, LH.(2009).Caulis Sinomenii Extracts Activate DA/NE Transporter and Inhibit 5HT Transporter.EXPERIMENTAL BIOLOGY AND MEDICINE,234(8),976-985. |
| MLA | Zhao, G,et al."Caulis Sinomenii Extracts Activate DA/NE Transporter and Inhibit 5HT Transporter".EXPERIMENTAL BIOLOGY AND MEDICINE 234.8(2009):976-985. |
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