Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus
文献类型：期刊论文
| 作者 | Zhang, KJ; Wang, YG; Cao, X; Zhong, SY; Wei, RC; Wu, YM; Yue, XT; Li, GC; Liu, XY |
| 刊名 | HUMAN GENE THERAPY
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:8页码:818-830 |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Interleukin (IL)-24 is an excellent therapeutic gene for cancer therapy. In this work, IL-24 was inserted into Ad.sp-E1A((Delta 24)), an oncolytic adenovirus with a 24-bp deletion in the E1A gene, which was driven by the survivin promoter to form Ad.sp-E1A((Delta 24))-IL-24. Ad.sp-E1A((Delta 24))-IL-24 has an excellent antitumor effect in vitro for human nasopharyngeal, liver, lung, and cervical carcinoma cell lines but does no or little damage to normal cell lines L-02 and WI38. Furthermore, it achieved nearly complete inhibition (although not elimination) of NCI-H460 lung carcinoma growth in nude mice. The antitumor efficacy of Ad.sp-E1A((Delta 24))-IL-24 on NCI-H460 cells was clearly mediated by apoptosis, because it induced caspase-3 and poly(ADP-ribose) polymerase cleavage. This is the first report of Ad.sp-E1A((Delta 24))-IL-24 with such an excellent, broad, and specific antitumor effect in vitro and nearly complete inhibition of lung tumor growth in vivo. |
| 学科主题 | Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 关键词[WOS] | DIFFERENTIATION-ASSOCIATED GENE-7 ; CELL LUNG-CANCER ; ANTI-APOPTOSIS GENE ; IN-VIVO ; HEPATOCELLULAR-CARCINOMA ; MITOCHONDRIAL APOPTOSIS ; SPINDLE CHECKPOINT ; COLORECTAL-CANCER ; VIRAL REPLICATION ; TUMOR-SUPPRESSOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269122400007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1227]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, KJ,Wang, YG,Cao, X,et al. Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus[J]. HUMAN GENE THERAPY,2009,20(8):818-830. |
| APA | Zhang, KJ.,Wang, YG.,Cao, X.,Zhong, SY.,Wei, RC.,...&Liu, XY.(2009).Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus.HUMAN GENE THERAPY,20(8),818-830. |
| MLA | Zhang, KJ,et al."Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus".HUMAN GENE THERAPY 20.8(2009):818-830. |
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