Molecular Mechanism of Tumor Suppression Activity of C/EBP beta mRNA 3 ' UTR: Simultaneous Deletion of 3 Short Sequences in The 3 ' UTR Reduces Its Tumor Suppression Activity
文献类型：期刊论文
| 作者 | Wang, HZ; Wang, Y; Sun, DQ; Liu, DG |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2009 |
| 卷号 | 36期号:9页码:1134-1140 |
| 关键词 | C/EBP beta 3 ' UTR tumor suppression activity moleculear mechanism |
| 通讯作者 | Liu, DG (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,dgliu@sibs.ac.cn |
| 英文摘要 | The 3' untranslated region of CCAAT/enhancer binding protein P(C/EBP beta) is a regulation element with tumor suppression activity found in previous study. Here, it is reported that deletion of 3 short sequences in this 3'UTR reduces the tumor suppression activity of it, as demonstrated by slowed-down cell growth, reduced colony formation ability in soft agar and in ordinary culture conditions, as well as the decreased tumorigenicity in nude mice. The cDNA array and real-time RT-PCR analysis showed that the loss of tumor suppression activity for the mutated 3' UTR was due to the change of the gene expression profile of the transfected cells, i.e. the up-regulation of several genes related with malignant phenotype and the down-regulation of some genes related with tumor suppression, compared with the revertant control cells. These results indicate that those short sequences are simultaneous necessary for the tumor suppression activity of the C/EBP beta 3'UTR. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | BREAST-CANCER ; TRANSLATIONAL CONTROL ; UNTRANSLATED REGIONS ; SYSTEMIC DELIVERY ; PROTEIN-KINASE ; PROHIBITIN ; GROWTH ; DIFFERENTIATION ; EXPRESSION ; 3'-UTR |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000270102300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1236]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, HZ,Wang, Y,Sun, DQ,et al. Molecular Mechanism of Tumor Suppression Activity of C/EBP beta mRNA 3 ' UTR: Simultaneous Deletion of 3 Short Sequences in The 3 ' UTR Reduces Its Tumor Suppression Activity[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2009,36(9):1134-1140. |
| APA | Wang, HZ,Wang, Y,Sun, DQ,&Liu, DG.(2009).Molecular Mechanism of Tumor Suppression Activity of C/EBP beta mRNA 3 ' UTR: Simultaneous Deletion of 3 Short Sequences in The 3 ' UTR Reduces Its Tumor Suppression Activity.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,36(9),1134-1140. |
| MLA | Wang, HZ,et al."Molecular Mechanism of Tumor Suppression Activity of C/EBP beta mRNA 3 ' UTR: Simultaneous Deletion of 3 Short Sequences in The 3 ' UTR Reduces Its Tumor Suppression Activity".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 36.9(2009):1134-1140. |
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