Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling
文献类型：期刊论文
| 作者 | Liu, ZD; Li, ZH; Mao, KR; Zou, J; Wang, Y; Tao, ZY; Lin, GM; Tian, L; Ji, YY; Wu, XD |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 183期号:10页码:6320-6329 |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Mol Immunol, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai, Peoples R China.,cxiang@zju.edu.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNA interference-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation. The Journal of Immunology, 2009, 183: 6320-6329. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | CD4 T-CELLS ; GENE-EXPRESSION ; TRANSCRIPTION FACTORS ; ACTIVATION ; MECHANISMS ; REPRESSION ; INDUCTION ; RESPONSES ; ELEMENTS ; HYPOXIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271765700034 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1239]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, ZD,Li, ZH,Mao, KR,et al. Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling[J]. JOURNAL OF IMMUNOLOGY,2009,183(10):6320-6329. |
| APA | Liu, ZD.,Li, ZH.,Mao, KR.,Zou, J.,Wang, Y.,...&Sun, B.(2009).Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling.JOURNAL OF IMMUNOLOGY,183(10),6320-6329. |
| MLA | Liu, ZD,et al."Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling".JOURNAL OF IMMUNOLOGY 183.10(2009):6320-6329. |
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