RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis
文献类型：期刊论文
| 作者 | Gong, XW; Ye, WY; Zhou, HB; Ren, XH; Li, ZG; Zhou, WY; Wu, J; Gong, YC; Qi, OY; Zhao, XL |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2009 |
| 卷号 | 41期号:11页码:883-891 |
| 关键词 | AChE RanBPM yeast two-hybrid cisplatin apoptosis |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn |
| 英文摘要 | Acetylcholinesterase (AChE) expression may be induced during apoptosis in various cell types. Here, we used the C-terminal of AChE to screen the human fetal brain library and found that it interacted with Ran-binding protein in the microtubule-organizing center (RanBPM). This interaction was further confirmed by coimmunoprecipitation analysis. In HEK293T cells, RanBPM and AChE were heterogeneously expressed in the cisplatin-untreated cytoplasmic extracts and in the cisplatin-treated cytoplasmic or nuclear extracts. Our previous studies performed using morphologic methods have shown that AChE translocates from the cytoplasm to the nucleus during apoptosis. Taken together, these results suggest that RanBPM is an AChE-interacting protein that is translocated from the cytoplasm into the nucleus during apoptosis, similar to the translocation observed in case of AChE. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | THYROID-HORMONE RECEPTORS ; PERIPHERAL ANIONIC SITE ; KINASE C-ABL ; EXTRACELLULAR-MATRIX ; CELL-MIGRATION ; DNA-DAMAGE ; IN-VITRO ; EXPRESSION ; ACTIVATION ; ADHESION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271563900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1253]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gong, XW,Ye, WY,Zhou, HB,et al. RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41(11):883-891. |
| APA | Gong, XW.,Ye, WY.,Zhou, HB.,Ren, XH.,Li, ZG.,...&Zhang, XJ.(2009).RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41(11),883-891. |
| MLA | Gong, XW,et al."RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41.11(2009):883-891. |
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