Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine
文献类型：期刊论文
| 作者 | Chang, ZL |
| 刊名 | BIOLOGY OF THE CELL
 |
| 出版日期 | 2009 |
| 卷号 | 101期号:12页码:709-721 |
| 关键词 | epigenetic modification innate and adaptive immunity microRNA (miRNA) macrophage monocyte transcription regulator gene |
| 通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,chang_zong_liang@hotmail.com |
| 英文摘要 | Monocytes/macrophages are critical for both immunity and homoeostasis. They are the outposts of the immune system in detecting invading pathogens or foreign antigens for homoeostatic clearance and antigen processing for the initiation and effector stages of both innate and adaptive immunity. In addition, monocytes/macrophages often function as control switches for immune system balance between pro- and anti-inflammatory reactions. In the beginning of this article, I would like to briefly introduce the achievements of Metchnikoff and Ehrlich in immunology, including Metchnikoff's cell theory, since they have both greatly influenced the advancement of modern immunology. Additionally, I will honour the 100th anniversary of the 1908 Nobel Prize in Physiology or Medicine. Next, I would like to emphasize the concept of the MPS (mononuclear phagocyte system) by examining recent developments regarding the MPS. Thus the article consists of three parts. The first part describes the regulation of growth and differentiation in the MPS. The second part addresses how the key macrophage transcription factor gene PU.1 and the csf1r (colony-stimulating factor-1 receptor gene) play a critical role in haematopoietic myelopoiesis, or the generation of the cells of the MPS. The third part describes PMA-induced monocyte/macrophage differentiation and immune modulation of suppressor macrophages. Finally, this review discusses the latest findings and implications regarding the MPS and macrophages. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | MURINE PERITONEAL-MACROPHAGES ; STIMULATING FACTOR-1 RECEPTOR ; TRANSCRIPTION FACTOR PU.1 ; TOLL-LIKE-RECEPTORS ; T-CELL FATE ; DENDRITIC CELLS ; STEM-CELLS ; FINE-STRUCTURE ; P38 MAPK ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272651000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1263]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chang, ZL. Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine[J]. BIOLOGY OF THE CELL,2009,101(12):709-721. |
| APA | Chang, ZL.(2009).Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine.BIOLOGY OF THE CELL,101(12),709-721. |
| MLA | Chang, ZL."Recent development of the mononuclear phagocyte system: in memory of Metchnikoff and Ehrlich on the 100th Anniversary of the 1908 Nobel Prize in Physiology or Medicine".BIOLOGY OF THE CELL 101.12(2009):709-721. |
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