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MicroRNA miR-326 regulates T-H-17 differentiation and is associated with the pathogenesis of multiple sclerosis
文献类型：期刊论文
| 作者 | Du, CS; Liu, C; Kang, JH; Zhao, GX; Ye, ZQ; Huang, SC; Li, ZX; Wu, ZY; Pei, G |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 10期号:12页码:1252-U4 |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Lab Mol Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | Interleukin 17 (IL-17)-producing T helper cells (T-H-17 cells) are increasingly recognized as key participants in various autoimmune diseases, including multiple sclerosis. Although sets of transcription factors and cytokines are known to regulate T-H-17 differentiation, the role of noncoding RNA is poorly understood. Here we identify a T-H-17 cell-associated microRNA, miR-326, whose expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). In vivo silencing of miR-326 resulted in fewer T-H-17 cells and mild EAE, and its overexpression led to more T-H-17 cells and severe EAE. We also found that miR-326 promoted T-H-17 differentiation by targeting Ets-1, a negative regulator of T-H-17 differentiation. Our data show a critical role for microRNA in T-H-17 differentiation and the pathogenesis of multiple sclerosis. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; NEUROMYELITIS-OPTICA ; CELL-DIFFERENTIATION ; IMMUNE-SYSTEM ; TH17 CELLS ; T-CELLS ; C-MYB ; DISEASE ; INTERLEUKIN-17 ; AUTOIMMUNITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271872800008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1266]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Du, CS,Liu, C,Kang, JH,et al. MicroRNA miR-326 regulates T-H-17 differentiation and is associated with the pathogenesis of multiple sclerosis[J]. NATURE IMMUNOLOGY,2009,10(12):1252-U4. |
| APA | Du, CS.,Liu, C.,Kang, JH.,Zhao, GX.,Ye, ZQ.,...&Pei, G.(2009).MicroRNA miR-326 regulates T-H-17 differentiation and is associated with the pathogenesis of multiple sclerosis.NATURE IMMUNOLOGY,10(12),1252-U4. |
| MLA | Du, CS,et al."MicroRNA miR-326 regulates T-H-17 differentiation and is associated with the pathogenesis of multiple sclerosis".NATURE IMMUNOLOGY 10.12(2009):1252-U4. |
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