Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment
文献类型：期刊论文
| 作者 | Yang, XO; Angkasekwinai, P; Zhu, JF; Peng, J; Liu, ZD; Nurieva, R; Liu, XK; Chung, Y; Chang, SH; Sun, B |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 10期号:12页码:1260-U5 |
| 通讯作者 | Dong, C (reprint author), Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, 1515 Holcombe Blvd, Houston, TX 77030 USA.,xoyang@mdanderson.org ; bsun@sibs.ac.cn ; cdong@mdanderson.org |
| 英文摘要 | How naive CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is poorly understood. Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells. CD4(+) T cells from Dec2- deficient mice showed defective T(H)2 differentiation in vitro and in vivo in an asthma model and in response to challenge with a parasite antigen. Dec2 promoted expression of interleukin 4 (IL-4), IL-5 and IL-13 during early T(H)2 differentiation and directly bound to and activated transcription of genes encoding the transcription factors JunB and GATA-3. As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | T-CELLS ; SCHISTOSOMA-MANSONI ; TH2 DIFFERENTIATION ; EXPRESSION ; RESPONSES ; GENE ; JUNB ; IL-2 ; IDENTIFICATION ; GENERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271872800009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1267]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, XO,Angkasekwinai, P,Zhu, JF,et al. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment[J]. NATURE IMMUNOLOGY,2009,10(12):1260-U5. |
| APA | Yang, XO.,Angkasekwinai, P.,Zhu, JF.,Peng, J.,Liu, ZD.,...&Dong, C.(2009).Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment.NATURE IMMUNOLOGY,10(12),1260-U5. |
| MLA | Yang, XO,et al."Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment".NATURE IMMUNOLOGY 10.12(2009):1260-U5. |
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