Mechanisms of microRNA-mediated gene regulation
文献类型：期刊论文
| 作者 | Zhao, S; Liu, MF |
| 刊名 | SCIENCE IN CHINA SERIES C-LIFE SCIENCES
 |
| 出版日期 | 2009 |
| 卷号 | 52期号:12页码:1111-1116 |
| 关键词 | miRNA repression activation de-repression processing bodies stress granules |
| 通讯作者 | Liu, MF (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,mfliu@sibs.ac.cn |
| 英文摘要 | microRNAs (miRNAs) are identified as a class of non-protein regulators and a new source for broad control of gene expression in eukaryotes. The past years have witnessed substantial progress in understanding miRNA functions and mechanisms, although a few controversies remain. Various hypotheses and models have been suggested for the mechanisms of miRNA repression, including translational inhibition at the level of initiation or elongation, rapid degradation of the nascent peptide, mRNA degradation, and mRNA sequestration into P bodies (processing bodies) and SGs (stress granules) for degradation or/and storage. Recently, some noncanonical miRNA regulation, such as miRNA activation and de-repression of miRNA inhibition, have been uncovered. This review discusses some recent advances about how miRNAs regulate their targets and various modes of miRNA function. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 类目[WOS] | Biology |
| 关键词[WOS] | MESSENGER-RNA ; TRANSLATION INITIATION ; POSTTRANSCRIPTIONAL REGULATION ; DEPENDENT LOCALIZATION ; ARGONAUTE PROTEINS ; LET-7 MICRORNA ; HUMAN-CELLS ; DEADENYLATION ; INHIBITION ; REPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272869700002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1269]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, S,Liu, MF. Mechanisms of microRNA-mediated gene regulation[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2009,52(12):1111-1116. |
| APA | Zhao, S,&Liu, MF.(2009).Mechanisms of microRNA-mediated gene regulation.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,52(12),1111-1116. |
| MLA | Zhao, S,et al."Mechanisms of microRNA-mediated gene regulation".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 52.12(2009):1111-1116. |
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