The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein
文献类型：期刊论文
| 作者 | Fu, QS; Song, AX; Li, SX; Hu, HY |
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2009 |
| 卷号 | 16期号:12页码:1442-1446 |
| 关键词 | LRRK2 ROC domain small GTPase GTP binding Parkinson's disease |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | KINASE-ACTIVITY ; P21(H-RAS) PROTEIN ; NEURONAL TOXICITY ; LIGAND-BINDING ; MUTATIONS ; GENE ; MECHANISM ; HYDROLYSIS ; INSIGHTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271620200005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1271]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fu, QS,Song, AX,Li, SX,et al. The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein[J]. PROTEIN AND PEPTIDE LETTERS,2009,16(12):1442-1446. |
| APA | Fu, QS,Song, AX,Li, SX,&Hu, HY.(2009).The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein.PROTEIN AND PEPTIDE LETTERS,16(12),1442-1446. |
| MLA | Fu, QS,et al."The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein".PROTEIN AND PEPTIDE LETTERS 16.12(2009):1442-1446. |
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