Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl
文献类型：期刊论文
| 作者 | Qin, YB; Li, L; Pan, WJ; Wu, DQ |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 284期号:34页码:22544-22548 |
| 通讯作者 | Pan, WJ (reprint author), Yale Univ, Sch Med, Vasc Biol & Therapeut Program, 333 Cedar St, New Haven, CT 06520 USA.,weijun.pan@yale.edu ; dan.wu@yale.edu |
| 英文摘要 | Wnt signaling plays important roles in various physiological and pathophysiological processes. The pathway that leads to beta-catenin stabilization is initiated by Wnt binding to its cell surface receptors, which induces the formation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via activation of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) type I. Here, we show that Wnt also stimulated the production of phosphatidylinositol 4-phosphate (PtdIns(4)P), which depended on Frizzled (Fz), Dishevelled (Dvl), and phosphatidylinositol 4-kinase (PI4K) type II alpha in HEK293T cells. Dvl directly interacted with and activated PI4KII alpha by increasing its V(max) for ATP and PtdIns. In addition, Dvl regulated PI4KII alpha and PIP5KI via different domains. Moreover, Dvl, PI4KII alpha, and PIP5KI appeared to form a ternary complex upon Wnt3a stimulation. This complex may allow efficient production of PtdIns(4,5)P(2) from PtdIns, which is far more abundant than PtdIns(4)P in cells. Therefore, this study provides new insights into the mechanism by which Wnt3a regulates the production of PtdIns(4,5)P(2). |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | LRP6 PHOSPHORYLATION ; SIGNALING PATHWAY ; DISEASE ; ACTIVATION ; PHOSPHOINOSITIDES ; MECHANISM ; AXIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268963100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1291]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Qin, YB,Li, L,Pan, WJ,et al. Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2009,284(34):22544-22548. |
| APA | Qin, YB,Li, L,Pan, WJ,&Wu, DQ.(2009).Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl.JOURNAL OF BIOLOGICAL CHEMISTRY,284(34),22544-22548. |
| MLA | Qin, YB,et al."Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl".JOURNAL OF BIOLOGICAL CHEMISTRY 284.34(2009):22544-22548. |
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