Overexpression of Csk-binding protein contributes to renal cell carcinogenesis
文献类型：期刊论文
| 作者 | Feng, X; Lu, X; Man, X; Zhou, W; Jiang, LQ; Knyazev, P; Lei, L; Huang, Q; Ullrich, A; Zhang, Z |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2009 |
| 卷号 | 28期号:37页码:3320-3331 |
| 关键词 | Csk-binding protein renal cell carcinoma carcinogenesis RhoA PDZ-binding motif |
| 通讯作者 | Chen, Z (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zhangzhe@sibs.ac.cn ; zjchen@sibs.ac.cn |
| 英文摘要 | C-terminal Src kinase (Csk)-binding protein (Cbp) is a transmembrane adaptor protein that localizes exclusively in lipid rafts, where it regulates Src family kinase (SFK) activities through recruitment of Csk. Although SFKs are well known for their involvement in cancer, the function of Cbp in carcinogenesis remains largely unknown. In this study, we reported overexpression of Cbp in more than 70% of renal cell carcinoma (RCC) specimens and in the majority of tested RCC cell lines. Depletion of Cbp in RCC cells by RNA interference led to remarkable inhibition of cell proliferation, migration, anchorage-independent growth as well as tumorigenicity in nude mice. Strikingly, silencing of Cbp negatively affected the sustaining of Erk1/2 activation but not c-Src activation induced by serum. Besides, the RhoA activity in RCC cells was remarkably impaired when Cbp was knocked down. Overexpression of wild-type Cbp, but not its mutant Cbp/Delta CP lacking C-terminal PDZ-binding motif, significantly enhanced RhoA activation and cell migration of RCC cells. These results provided new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis. Oncogene (2009) 28, 3320-3331; doi:10.1038/onc.2009.185; published online 6 July 2009 |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 关键词[WOS] | TRANSMEMBRANE ADAPTER PROTEIN ; FAMILY TYROSINE KINASES ; LIPID RAFTS ; DOWN-REGULATION ; CARCINOMA ; SRC ; ACTIVATION ; PHOSPHOPROTEIN ; CYTOSKELETON ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269893700006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1295]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Feng, X,Lu, X,Man, X,et al. Overexpression of Csk-binding protein contributes to renal cell carcinogenesis[J]. ONCOGENE,2009,28(37):3320-3331. |
| APA | Feng, X.,Lu, X.,Man, X.,Zhou, W.,Jiang, LQ.,...&Chen, Z.(2009).Overexpression of Csk-binding protein contributes to renal cell carcinogenesis.ONCOGENE,28(37),3320-3331. |
| MLA | Feng, X,et al."Overexpression of Csk-binding protein contributes to renal cell carcinogenesis".ONCOGENE 28.37(2009):3320-3331. |
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