MSC p43 required for axonal development in motor neurons
文献类型：期刊论文
| 作者 | Zhu, XD; Liu, Y; Yin, YQ; Shao, AY; Zhang, B; Kim, S; Zhou, JW |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2009 |
| 卷号 | 106期号:37页码:15944-15949 |
| 关键词 | assembly axon degeneration multisynthetase complex neurofilament |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China.,jwzhou@ion.ac.cn |
| 英文摘要 | Neuron connectivity and correct neural function largely depend on axonal integrity. Neurofilaments (NFs) constitute the main cytoskeletal network maintaining the structural integrity of neurons and exhibit dynamic changes during axonal and dendritic growth. However, the mechanisms underlying axonal development and maintenance remain poorly understood. Here, we identify that multisynthetase complex p43 (MSC p43) is essential for NF assembly and axon maintenance. The MSC p43 protein was predominantly expressed in central neurons and interacted with NF light subunit in vivo. Mice lacking MSC p43 exhibited axon degeneration in motor neurons, defective neuromuscular junctions, muscular atrophy, and motor dysfunction. Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs. Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | TRANSFER-RNA SYNTHETASE ; MULTIFUNCTIONAL PROTEIN 1/P43 ; INTERMEDIATE-FILAMENTS ; TAIL DOMAINS ; DISEASE ; PHOSPHORYLATION ; ARCHITECTURE ; NEUROFILAMENTS ; TRANSPORT ; MUTATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269806600078 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1296]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, XD,Liu, Y,Yin, YQ,et al. MSC p43 required for axonal development in motor neurons[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(37):15944-15949. |
| APA | Zhu, XD.,Liu, Y.,Yin, YQ.,Shao, AY.,Zhang, B.,...&Zhou, JW.(2009).MSC p43 required for axonal development in motor neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(37),15944-15949. |
| MLA | Zhu, XD,et al."MSC p43 required for axonal development in motor neurons".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.37(2009):15944-15949. |
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