Characterization of a novel isoform of murine interferon regulatory factor 3
文献类型：期刊论文
| 作者 | Zhai, JW; Gao, DM; Liu, W; Hong, R; Qin, Y; Ouyang, HF; Kong, YY; Wang, YA; Xie, YH; Liu, J |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008 |
| 卷号 | 377期号:2页码:384-388 |
| 关键词 | IFN-beta mIRF-3 mIRF-3a |
| 通讯作者 | Xie, YH (reprint author), Fudan Univ, Key Lab Med Mol Virol, Inst Med Microbiol, Shanghai Med Coll, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.,yhxie@sibs.ac.cn ; liujing212@fudan.edu.cn |
| 英文摘要 | Interferon (IFN) regulatory factors (IRFs) are a family of transcription mediators involved in the regulation of type I IFN (IFN-alpha/beta) transcription. Among the nine already identified IRFs, IRF-3 is a constitutively and ubiquitously expressed and plays a critical role in the transcriptional activation of type I IFN and IFN-stimulated genes including IFN-alpha 1, IFN-beta and RANTES. In the present study, we report the identification of a novel alternatively spliced transcript of murine Irf-3 gene (mIrf-3) designated mIRF-3a. mIRF-3a is ubiquitously present in mouse tissues along with mIRF-3 and could be translocated into the nucleus in uninfected L929 cells. EMSA and reporter assay demonstrated that mIRF-3a binds to ISRE sequences in murine Ifn-beta promoter and represses Ifn-beta promoter activation induced by Newcastle disease Virus infection. These results suggest that mIRF-3a may act as a modulator of mIRF-3 functions in vivo. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | DOUBLE-STRANDED-RNA ; STIMULATED RESPONSE ELEMENT ; IRF-3 TRANSCRIPTION FACTOR ; FACTOR FAMILY ; VIRUS-INFECTION ; IN-VIVO ; BINDING ; GENE ; ACTIVATION ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261301600012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1329]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhai, JW,Gao, DM,Liu, W,et al. Characterization of a novel isoform of murine interferon regulatory factor 3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,377(2):384-388. |
| APA | Zhai, JW.,Gao, DM.,Liu, W.,Hong, R.,Qin, Y.,...&Liu, J.(2008).Characterization of a novel isoform of murine interferon regulatory factor 3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,377(2),384-388. |
| MLA | Zhai, JW,et al."Characterization of a novel isoform of murine interferon regulatory factor 3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377.2(2008):384-388. |
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