Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons
文献类型：期刊论文
| 作者 | Huang, MG; Huang, TW; Xiang, Y; Xie, ZQ; Chen, Y; Yan, R; Xu, JY; Cheng, LP |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 322期号:2页码:394-405 |
| 关键词 | Glycine Peptides Ptf1a Lbx1 Pax2 Tlx genes Dorsal horn Spinal cord Neurotransmitter Inhibitory neuron |
| 通讯作者 | Cheng, LP (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lpcheng@sibs.ac.cn |
| 英文摘要 | inhibitory neurons in the dorsal horn synthesize a variety of neurotransmitters, including GABA, glycine and a set of peptides. Here we show that three transcription factors, Prf1a, Pax2, and Lbx1, which have been reported to promote a GABAergic cell fate, also specify glycinergic and peptidergic transmitter phenotypes. First, Prf1a appears to be a master regulator, as indicated by a requirement of Prf1a for the expression of glycinergic marker GlyT2 and a set of peptides, including neuropeptide Y (NPY), nociceptin/orphanin FQ(N/OFQ). somatostatin (SOM), enkephalin (ENK), dynorphin (DYN) and galanin (GAL). Second, Pax2 is a downstream target of Prf1a and controls subsets of transmitter phenotypes, including the expression of GlyT2, NPY, N/OFQ, DYN, and GAL, but is dispensable for SOM OF ENK expression. Third, for Lbx1, due to neuronal cell loss at late stages, our analyses focused on early embryonic stages, and we found that Lbx1 is required for the expression of GlyT2, NPY, N/OFQ and is partially responsible for SOM expression. Our Studies therefore Suggest a coordinated and hierarchical specification of a variety of neurotransmitters in dorsal spinal inhibitory neurons. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | GABAERGIC NEURONS ; PATHOLOGICAL PAIN ; TRANSPORTER GLYT2 ; OPIOID-PEPTIDES ; HOMEOBOX GENES ; CELL FATE ; CORD ; HORN ; RAT ; INTERNEURONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260150200014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1330]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, MG,Huang, TW,Xiang, Y,et al. Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons[J]. DEVELOPMENTAL BIOLOGY,2008,322(2):394-405. |
| APA | Huang, MG.,Huang, TW.,Xiang, Y.,Xie, ZQ.,Chen, Y.,...&Cheng, LP.(2008).Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.DEVELOPMENTAL BIOLOGY,322(2),394-405. |
| MLA | Huang, MG,et al."Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons".DEVELOPMENTAL BIOLOGY 322.2(2008):394-405. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。