Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor
文献类型：期刊论文
| 作者 | Fan, JK; Xiao, T; Gu, JF; Wei, N; He, LF; Ding, M; Liu, XY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008 |
| 卷号 | 374期号:2页码:198-203 |
| 关键词 | oncolytic adenovirus mutant kringle 5 antiangiogenesis tumor inhibition |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Angiogenesis plays a key role in the development of a wide variety of malignant tumors. The approach of targeting antiangiogenesis has become an important field of cancer gene therapy. In this study, the antiangiogenesis protein K5 (the kringle 5 of human plasminogen) has been mutated by changing leucine71 to arginine to form mK5. Then the ZD55-mK5, which is an oncolytic adenovirus expressing mK5, was constructed. It showed stronger inhibition on proliferation of human umbilical vein endothelial cell. Moreover, in tube formation and embryonic chorioallantoic membrane assay, ZD55-mK5 exhibited more effective antiangiogenesis than ZD55-K5. In addition, ZD55-mK5 generated obvious suppression on the growth of colorectal tumor xenografts and prolonged the life span of nude mice. These results indicate that ZD55-mK5 is a potent agent for inhibiting the tumor angiogenesis and tumor growth. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | HUMAN PLASMINOGEN ; ANTITUMOR-ACTIVITY ; ANGIOGENESIS ; KRINGLE-5 ; CANCER ; INHIBITOR ; APOPTOSIS ; GROWTH ; CELLS ; TRAIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258600100005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1331]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fan, JK,Xiao, T,Gu, JF,et al. Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,374(2):198-203. |
| APA | Fan, JK.,Xiao, T.,Gu, JF.,Wei, N.,He, LF.,...&Liu, XY.(2008).Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,374(2),198-203. |
| MLA | Fan, JK,et al."Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 374.2(2008):198-203. |
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