Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans
文献类型：期刊论文
| 作者 | Mao, XM; Li, YD; Wang, HF; Cao, F; Chen, JY |
| 刊名 | FEMS MICROBIOLOGY LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 285期号:2页码:233-241 |
| 关键词 | Swi1 Tup1 Candida albicans filamentous growth |
| 通讯作者 | Chen, JY (reprint author), Chinese Acad Sci, SIBS, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jychen@sunm.shcnc.ac.cn |
| 英文摘要 | Candida albicans is a polymorphic human opportunistic pathogen in which the Swi-Snf complex functions as an activator whereas Tup1 acts as a general repressor during the yeast-hyphae transition. In Saccharomyces cerevisiae, the interplay between the Swi-Snf complex and the Tup1-Ssn6 repressive complex regulates the balance between active and repressed chromatin structures of a number of genes. To study the interplay between Candida albicans Swi1 and Tup1 and their effects on morphogenesis, we analyzed phenotypes of swi1/swi1, tup1/tup1 and swi1/swi1 tup1/tup1 mutants under various growth conditions. The swi1/swi1 mutant failed to form true hyphae, whereas the tup1/tup1 mutant exhibited constitutive filamentous growth. Deletion of SWI1 in the tup1/tup1 mutant completely blocked hyphal growth under all the conditions examined. Under aerobic conditions, the swi1/swi1 tup1/tup1 mutant most resembled the swi1/swi1 mutant in phenotype, actin polarization and gene expression pattern. In invaded agar, the double mutant showed similar phenotypes as the swi1/swi1 mutant, while under embedded conditions, it grew as a pseudohypha-like form different from that of the wild-type strain, swi1/swi1 or tup1/tup1 mutants. These results suggest that Swi1 may play a dominant role by antagonizing the repressive effect of the Tup1 on hyphal development in C. albicans. |
| 学科主题 | Microbiology |
| 类目[WOS] | Microbiology |
| 关键词[WOS] | HYPHAL DEVELOPMENT ; FUNGAL PATHOGEN ; SACCHAROMYCES-CEREVISIAE ; GENE ; YEAST ; EXPRESSION ; MORPHOGENESIS ; VIRULENCE ; SNF ; CONSTRUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257659100014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1332]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mao, XM,Li, YD,Wang, HF,et al. Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans[J]. FEMS MICROBIOLOGY LETTERS,2008,285(2):233-241. |
| APA | Mao, XM,Li, YD,Wang, HF,Cao, F,&Chen, JY.(2008).Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans.FEMS MICROBIOLOGY LETTERS,285(2),233-241. |
| MLA | Mao, XM,et al."Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans".FEMS MICROBIOLOGY LETTERS 285.2(2008):233-241. |
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