Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia
文献类型：期刊论文
| 作者 | Zhao, YM; Li, WM; Chow, PCY; Lau, DTK; Lee, NTK; Pang, YP; Zhang, XJ; Wang, XL; Han, YF |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 439期号:2页码:160-164 |
| 关键词 | bis(7)-tacrine cerebral ischemia stroke multiple targets memantine |
| 通讯作者 | Han, YF (reprint author), Hong Kong Polytech Univ, Inst Modern Chinese Med, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China.,ymzhao@ust.hk ; Yifan.HAN@inet.polyu.edu.hk |
| 英文摘要 | Bis(7)-tacrine, a promising anti-Alzheimer's dimer, has been shown to have multiple neuroprotective activities in vitro. Here, we investigate whether bis(7)-tacrine attenuates focal cerebral ischemic impairment in vivo. Cerebral ischemia was induced in Sprague-Dawley rats by transient (2 h) middle cerebral artery occlusion (MCAO) followed by 24h of reperfusion. Bis(7)-tacrine administered intraperitoneally 15 min after ischemia dose-dependently improved neurological behavior deficits and reduced both cerebral infarct volume and edema. The TUNEL staining assay showed that bis(7)-tacrine attenuated neuronal apoptosis in the penumbral region. Compared with that for memantine, a moderately effective N-methyl-D-aspartate (NMDA) receptor antagonist with a similar affinity and potency to bis(7)-tacrine in blocking NMDA receptors, the therapeutic window for bis(7)-tacrine was wider and lasted up to 6 h after the onset of ischemia. Bis(7)-tacrine did not affect physiological parameters or regional cerebral blood flow during either the occlusion period or the early reperfusion stage. In conclusion, bis(7)-tacrine close- and time-dependently protected against acute focal cerebral ischemic insults, possibly through the drug's anti-apoptotic effects during multiple events in the ischemic cascade. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | INDUCED NEURONAL APOPTOSIS ; NITRIC-OXIDE SYNTHASE ; D-ASPARTATE RECEPTORS ; RATS ; MEMANTINE ; DISEASE ; STROKE ; INJURY ; MODEL ; ACETYLCHOLINESTERASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257548500010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1333]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, YM,Li, WM,Chow, PCY,et al. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia[J]. NEUROSCIENCE LETTERS,2008,439(2):160-164. |
| APA | Zhao, YM.,Li, WM.,Chow, PCY.,Lau, DTK.,Lee, NTK.,...&Han, YF.(2008).Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia.NEUROSCIENCE LETTERS,439(2),160-164. |
| MLA | Zhao, YM,et al."Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia".NEUROSCIENCE LETTERS 439.2(2008):160-164. |
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