Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer
文献类型：期刊论文
| 作者 | Zhang, Y; Qin, X; Zhang, Y; Zhao, L; Wang, Y; Liu, X; Yao, L |
| 刊名 | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 134期号:2页码:219-226 |
| 关键词 | ZD55 MnSOD 5-FU adenovirus gene-virotherapy colorectal cancer |
| 通讯作者 | Yao, LQ (reprint author), Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China.,may7523@hotmail.com |
| 英文摘要 | Purpose ZD55-MnSOD is an E1B 55 kDa-deleted replication-competent adenovirus and armed with the therapeutic gene MnSOD. The expression of the therapeutic gene MnSOD increases with the selective replication of the oncolytic adenovirus (ZD55) so that ZD55-MnSOD has more significant activity than the replicate defective adenovirus Ad-MnSOD in vitro and in vivo. The tumor cannot be completely eradicated only with ZD55-MnSOD, although ZD55-MnSOD has obvious antitumor activity. 5-fluorouracil (5-FU) is still the most effective adjuvant therapy for patients with colorectal cancer. Methods We reasoned that combined treatment of cancer cells with ZD55-MnSOD and 5-FU might have a synergistic effect. In vitro experiments with SW620 colorectal carcinoma cell line demonstrated that it was sensitive to ZD55-MnSOD, especially most sensitive to ZD55-MnSOD plus 5-FU treatment. Treatment with both ZD55-MnSOD and 5-FU could induce more significant apoptosis in cancer cells compared with ZD55-MnSOD or 5-FU alone, respectively. A better antitumor activity was observed by ZD55-MnSOD plus 5-fluorouracil (5-FU) treatment. Tumor growth was greatly inhibited by this combined treatment, and animal survival time increased. Conclusion These results show that, by using the combination therapies, a significant decrease in tumor mass can be achieved, which suggest that ZD55-MnSOD in combination with 5-FU may have potential clinical implications. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | MANGANESE SUPEROXIDE-DISMUTASE ; POUCH CARCINOMA-CELLS ; TUMOR-SUPPRESSOR GENE ; MALIGNANT PHENOTYPE ; ANTIOXIDANTS ENHANCE ; REACTIVE OXYGEN ; GLIOMA-CELLS ; GROWTH ; OVEREXPRESSION ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251487000013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1344]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Qin, X,Zhang, Y,et al. Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2008,134(2):219-226. |
| APA | Zhang, Y.,Qin, X.,Zhang, Y.,Zhao, L.,Wang, Y.,...&Yao, L.(2008).Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,134(2),219-226. |
| MLA | Zhang, Y,et al."Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 134.2(2008):219-226. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。