Hypoalgesia in mice lacking GABA transporter subtype
文献类型：期刊论文
| 作者 | Xu, YF; Cai, YQ; Cai, GQ; Jiang, J; Sheng, ZJ; Wang, ZG; Fei, J |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 86期号:2页码:465-470 |
| 关键词 | GABA transporter tail-immersion test hot-plate test abdominal constriction test formalin test |
| 通讯作者 | Fei, J (reprint author), Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China.,jfeil24@126.com |
| 英文摘要 | gamma-Aminobutyric acid (GABA) transporters play a key role in the regulation of GABA neurotransmission. We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesia in mice. In the present study, nociceptive responses of GAT1-knockout mice (GAT1(-/-)) were compared with those of heterozygous (GAT(+/-)) and wild-type (GAT(+/+)) mice by four conventional pain models (tail-immersion test, hot-plate test, acetic acid-induced abdominal constriction test, and formalin test). In addition, the analgesic effects of two GAT1-selective inhibitors, NO-711 and tiagabine, were examined in all three genotypes using the same four models. Our data demonstrated that GAT1 deficiency because of genetic knockout or acute blockade by selective inhibitors leads to hypoalgesia in mice. These results confirmed the crucial role of GAT1 in the regulation of nociceptive threshold and suggested that GAT1 inhibitors have the potential for clinical use in pain therapy. (C) 2007 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | FACIAL CARRAGEENAN INJECTIONS ; BRAIN-STEM ; MOUSE ; HYPERALGESIA ; NOCICEPTION ; GABAPENTIN ; ACTIVATION ; EXPRESSION ; ANALGESIA ; TIAGABINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253005300025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1346]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, YF,Cai, YQ,Cai, GQ,et al. Hypoalgesia in mice lacking GABA transporter subtype[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(2):465-470. |
| APA | Xu, YF.,Cai, YQ.,Cai, GQ.,Jiang, J.,Sheng, ZJ.,...&Fei, J.(2008).Hypoalgesia in mice lacking GABA transporter subtype.JOURNAL OF NEUROSCIENCE RESEARCH,86(2),465-470. |
| MLA | Xu, YF,et al."Hypoalgesia in mice lacking GABA transporter subtype".JOURNAL OF NEUROSCIENCE RESEARCH 86.2(2008):465-470. |
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