Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis
文献类型：期刊论文
| 作者 | Qian, W; Liu, J; Tong, Y; Yan, S; Yang, C; Yang, M; Liu, X |
| 刊名 | LEUKEMIA
 |
| 出版日期 | 2008 |
| 卷号 | 22期号:2页码:361-369 |
| 关键词 | replication-competent adenovirus MDA-7 interleukin-24 apoptosis |
| 通讯作者 | Qian, W (reprint author), Zhejiang Univ, First Affiliated Hosp, Dept Hematol,Minist Publ Hlth, Inst Hematol,Coll Med,Key Lab Combined Multiorgan, 79 Qingchun Rd, Hangzhou 310003, Peoples R China.,qianwenb@hotmail.com |
| 英文摘要 | Conditionally replicating adenoviruses (CRAds) represent a promising new platform for anticancer therapy. However, CRAds have been evaluated little in hematopoietic malignancies because of the lack of expression of coxsackie adenovirus receptor (CAR) on their cell surface. In this study, we showed that CAR was expressed on two types of lymphoblastic leukemia cell lines and primary leukemia cells, and that ZD55, a CRAd, exerted a potent antileukemia effect in vitro and in vivo. Furthermore, ZD55 expressing melanoma differentiation-associated gene-7/interleukin-24 (ZD55-IL-24) elicited significant enhanced antileukemia activity comparing with ZD55, concomitant with upregulation of RNA-dependent protein kinase R (PKR), increased phosphorylation of p38 mitogen-activated protein kinase (MAPK), and induction of endoplasmic reticulum (ER) stress. These data for the first time indicate that MDA-7/IL24 exerts its antitumor effect on leukemia cells via multiple pathways, and suggest that oncolytic adenoviruses, ZD55 and ZD55-IL-24 could potentially be used against CAR-expressing hematological malignancies such as B-lymphoblastic leukemia/ lymphoma and some myeloid leukemia. |
| 学科主题 | Oncology; Hematology |
| 类目[WOS] | Oncology ; Hematology |
| 关键词[WOS] | DIFFERENTIATION-ASSOCIATED GENE-7 ; CANCER-SPECIFIC APOPTOSIS ; PHASE-I TRIAL ; ONCOLYTIC ADENOVIRUS ; TRANSGENE EXPRESSION ; DELETED ADENOVIRUS ; COLORECTAL-CANCER ; MELANOMA-CELLS ; OVARIAN-CANCER ; UP-REGULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253166900018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1347]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Qian, W,Liu, J,Tong, Y,et al. Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis[J]. LEUKEMIA,2008,22(2):361-369. |
| APA | Qian, W.,Liu, J.,Tong, Y.,Yan, S.,Yang, C.,...&Liu, X.(2008).Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis.LEUKEMIA,22(2),361-369. |
| MLA | Qian, W,et al."Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis".LEUKEMIA 22.2(2008):361-369. |
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