GSK3 beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis
文献类型：期刊论文
| 作者 | Jing, P; Jin, QH; Wu, J; Zhang, XJ |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 104期号:2页码:409-419 |
| 关键词 | A23187 acetylcholinesterase apoptosis glycogen synthase kinase-3 beta PC12 cells thapsigargin |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab,Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn |
| 英文摘要 | Besides its role in terminating acetylcholine-mediated neurotransmission, acetylcholinesterase (AChE) is found to be expressed and participate in the process of apoptosis in various cell types. However, the mechanisms underlying AChE up-regulation in neuronal cells remain elusive. Herein we demonstrated that glycogen synthase kinase-3 beta (GSK3 beta) mediates induced AChE-S expression during apoptosis. In this study, A23187 and thapsigargin (TG) were employed to induce apoptosis in neuroendocrine PC12 cells. The results showed that exposure of PC12 cells to A23187 and TG up-regulated AChE activity significantly. The same treatment also led to activation of GSK3 beta. Two different inhibitors of GSK3 beta (lithium and GSK3 beta-specific inhibitor VIII) could block A23187- or TG-induced up-regulation of AChE activity, AChE-S mRNA level and protein expression. However, lithium could not inhibit the induction of AChE-R mRNA and protein under similar conditions. Taken together, our results show that GSK3 beta is specifically involved in the induction of AChE-S expression in PC12 cells during apoptosis. |
| 学科主题 | Biochemistry & Molecular Biology; Neurosciences & Neurology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 关键词[WOS] | GLYCOGEN-SYNTHASE KINASE-3 ; ALZHEIMERS-DISEASE ; CALCIUM IONOPHORE ; MESSENGER-RNA ; IN-VITRO ; NEUROBLASTOMA-CELLS ; NEURITE OUTGROWTH ; CHOLINESTERASES ; STRESS ; NEURONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251765800012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1349]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jing, P,Jin, QH,Wu, J,et al. GSK3 beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis[J]. JOURNAL OF NEUROCHEMISTRY,2008,104(2):409-419. |
| APA | Jing, P,Jin, QH,Wu, J,&Zhang, XJ.(2008).GSK3 beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis.JOURNAL OF NEUROCHEMISTRY,104(2),409-419. |
| MLA | Jing, P,et al."GSK3 beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis".JOURNAL OF NEUROCHEMISTRY 104.2(2008):409-419. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。