Glucocorticoid-induced apoptosis requires FOXO3A activity
文献类型：期刊论文
| 作者 | Ma, JX; Xie, YH; Shi, Y; Qin, WM; Zhao, BT; Jin, YX |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008 |
| 卷号 | 377期号:3页码:894-898 |
| 关键词 | Glucocorticoids Forkhead transcription factor FOXO3A Apoptosis Phosphorylation Dexamethasone induced cell death |
| 通讯作者 | Xie, YH (reprint author), Fudan Univ, Huashan Hosp Affiliated, Dept Hematol, Shanghai 200040, Peoples R China.,xyh@medmail.com.cn ; yxjin@sibs.ac.cn |
| 英文摘要 | Dexamethasone (DEX) induces apoptosis in lymphocytes, while protecting some cancer cells from apoptosis, by a poorly understood mechanism. In this study, we examined the potential role of the forkhead transcription factor (FOXO3A) in DEX-induced apoptosis. Unphosphorylated FOXO3A. the active form of FOXO3A, can translocate into nucleus and induce apoptosis. In lymphocytes, FOXO3A is upregulated by DEX treatment, while phospho-FOXO3A was downregulated. In several different types of cancer cells, we found that sensitivity to DEX correlated negatively to expression of phospho-FOXO3A. We Conclude that DEX might maintain FOXO3A in its unphosphorylated, active form. Knockdown of FOXO3A expression using a small interfering RNA (siRNA) significantly reduces apoptosis in lymphocytes. This Study Suggests that FOXO3A has a pivotal role in DEX-induced apoptosis. Increased phospho-FOXO3A levels in cancer cells may explain. in part, their resistance to apoptosis. Therefore, FOXO3A may be a potential target for cancer therapy. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | FORKHEAD TRANSCRIPTION FACTORS ; CELL-SURVIVAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261458900030 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1352]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ma, JX,Xie, YH,Shi, Y,et al. Glucocorticoid-induced apoptosis requires FOXO3A activity[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,377(3):894-898. |
| APA | Ma, JX,Xie, YH,Shi, Y,Qin, WM,Zhao, BT,&Jin, YX.(2008).Glucocorticoid-induced apoptosis requires FOXO3A activity.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,377(3),894-898. |
| MLA | Ma, JX,et al."Glucocorticoid-induced apoptosis requires FOXO3A activity".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377.3(2008):894-898. |
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