Acute toxicity and irritation magnetic of water-based dextran-coated magnetic fluid injected in mice
文献类型：期刊论文
| 作者 | Zhai, Y; Wang, XL; Wang, XM; Xie, H; Gu, HC |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2008 |
| 卷号 | 85A期号:3页码:582-587 |
| 关键词 | magnetic fluid acute toxicity irritation subcutaneous injection dextran |
| 通讯作者 | Zhai, Y (reprint author), Shanghai Jiao Tong Univ, Res Inst Micro Nanometer Sci & Technol, Shanghai 200030, Peoples R China.,hcgu@sjtu.edu.cn |
| 英文摘要 | Based on the elements that magnetic nanoparticles could heat in an alternating magnetic field, magnetic fluid hyperthermia occurred to inhibit tumor growth in vivo. However, biocompatibility of those fluids as well as the fluid-body interaction remains unclear. In this article, acute toxicity and irritation of the water-based dextran-coated magnetic fluid (dextran-magnetic fluid) injected into mice subcutaneous tissues were examined. Lethal dosage 50 of single treatment with the magnetic fluid was 4409.61 +/- 514.93 mg/kg. When injected with 30 mg/0.3 nil, dextran-magnetic fluid, activities of glutamicoxalacetictransaminase (AST) and glutamicpyruvictransamine (ALT) and cell number of mice blood did not change statistically. Hemangiectasia and leucocytes infiltration were seen in subcutaneous tissues and these phenomena almost disappeared 72 h later. That is to say, the dextran-magnetic fluid was tolerable, safe, and biocompatible. The work is a basic for application of the dextran-magnetic fluid in subcutaneous tumor therapy. (C) 2007 Wiley Periodicals, Inc. |
| 学科主题 | Engineering; Materials Science |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 关键词[WOS] | IRON-OXIDE NANOPARTICLES ; PROSTATE-CANCER ; HYPERTHERMIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255530500002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1356]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhai, Y,Wang, XL,Wang, XM,et al. Acute toxicity and irritation magnetic of water-based dextran-coated magnetic fluid injected in mice[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2008,85A(3):582-587. |
| APA | Zhai, Y,Wang, XL,Wang, XM,Xie, H,&Gu, HC.(2008).Acute toxicity and irritation magnetic of water-based dextran-coated magnetic fluid injected in mice.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,85A(3),582-587. |
| MLA | Zhai, Y,et al."Acute toxicity and irritation magnetic of water-based dextran-coated magnetic fluid injected in mice".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 85A.3(2008):582-587. |
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