Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy
文献类型：期刊论文
| 作者 | Zhang, J; Gan, Y; Gu, JF; Hu, JY; Liu, XY; Zhao, XT |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2008 |
| 卷号 | 20期号:5页码:1035-1040 |
| 关键词 | hepatocellular carcinoma suppressor 1 conditionally replication-competent adenovirus progression elevated gene-3 promoter gene therapy hepatocellular carcinoma |
| 通讯作者 | Zhao, XT (reprint author), Shanghai Canc Inst, Cellular & Mol Immunol Lab, Shanghai 200032, Peoples R China.,xtzhao@online.sh.cn |
| 英文摘要 | We previously demonstrated that hepatocellular carcinoma suppressor 1 (HCCS1) exerts potent anti-tumor activity. In this study, we constructed a new dual tumor-targeting oncolytic adenovirus vector, PD55-HCCS1, in which E1A was driven by the promoter of progression elevated gene-3, which is hepatoma-specific, and a CMV-HCCS1 expression cassette replaced E1B55. The PD55-HCCS1-mediated selective expression of E1A and HCCS1 in hepatoma cells and tumor-selective cytotoxicity in vitro and in vivo demonstrated the strongest inhibition of BEL-7404 cell xenografts in nude mice among a number of control Ad vectors. These data indicated the efficacy and safety of the PD55-HCCS1 system for HCC treatment. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | HUMAN HEPATOCELLULAR-CARCINOMA ; CHROMOSOME 17P13.3 ; THERAPY ; ADENOVIRUS ; CANCER ; REPLICATION ; CELLS ; PROGRESSION ; EXPRESSION ; PROMOTER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260648200006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1371]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, J,Gan, Y,Gu, JF,et al. Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy[J]. ONCOLOGY REPORTS,2008,20(5):1035-1040. |
| APA | Zhang, J,Gan, Y,Gu, JF,Hu, JY,Liu, XY,&Zhao, XT.(2008).Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy.ONCOLOGY REPORTS,20(5),1035-1040. |
| MLA | Zhang, J,et al."Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy".ONCOLOGY REPORTS 20.5(2008):1035-1040. |
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