Candida albicans, a distinctive fungal model for cellular aging study
文献类型：期刊论文
| 作者 | Fu, XH; Meng, FL; Hu, Y; Zhou, JQ |
| 刊名 | AGING CELL
 |
| 出版日期 | 2008 |
| 卷号 | 7期号:5页码:746-757 |
| 关键词 | aging Candida albicans extra-chromosomal rDNA molecules model old cell preparation SIR2 |
| 通讯作者 | Zhou, JQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Max Planck Jr Res Grp,State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jqzhou@sibs.ac.cn |
| 英文摘要 | The unicellular eukaryotic organisms represent the popular model systems to understand aging in eukaryotes. Candida albicans, a polymorphic fungus, appears to be another distinctive unicellular aging model in addition to the budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe. The two types of Candida cells, yeast (blastospore) form and hyphal (filamentous) form, have similar replicative lifespan. Taking the advantage of morphologic changes, we are able to obtain cells of different ages. Old Candida cells tend to accumulate glycogen and oxidatively damaged proteins. Deletion of the SIR2 gene causes a decrease of lifespan, while insertion of an extra copy of SIR2 extends lifespan, indicating that like in S. cerevisiae, Sir2 regulates cellular aging in C. albicans. Interestingly, Sir2 deletion does not result in the accumulation of extra-chromosomal rDNA molecules, but influences the retention of oxidized proteins in mother cells, suggesting that the extra-chromosomal rDNA molecules may not be associated with cellular aging in C. albicans. This novel aging model, which allows efficient large-scale isolation of old cells, may facilitate biochemical characterizations and genomics/proteomics studies of cellular aging, and help to verify the aging pathways observed in other organisms including S. cerevisiae. |
| 学科主题 | Cell Biology ; Geriatrics & Gerontology |
| 类目[WOS] | Cell Biology ; Geriatrics & Gerontology |
| 关键词[WOS] | EXTENDS LIFE-SPAN ; SACCHAROMYCES-CEREVISIAE ; CALORIE RESTRICTION ; YEAST-CELLS ; PROTEIN OXIDATION ; DAUGHTER CELLS ; RIBOSOMAL DNA ; MOTHER CELLS ; SIR2 ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259307000015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1372]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fu, XH,Meng, FL,Hu, Y,et al. Candida albicans, a distinctive fungal model for cellular aging study[J]. AGING CELL,2008,7(5):746-757. |
| APA | Fu, XH,Meng, FL,Hu, Y,&Zhou, JQ.(2008).Candida albicans, a distinctive fungal model for cellular aging study.AGING CELL,7(5),746-757. |
| MLA | Fu, XH,et al."Candida albicans, a distinctive fungal model for cellular aging study".AGING CELL 7.5(2008):746-757. |
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