Mammalian DNMTs in the male germ line DNA of Drosophila
文献类型：期刊论文
| 作者 | Weyrich, A; Tang, XJ; Xu, GL; Schrattenholz, A; Hunzinger, C; Hennig, W |
| 刊名 | BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
 |
| 出版日期 | 2008 |
| 卷号 | 86期号:5页码:380-385 |
| 关键词 | Drosophila DNA methylation male germ line spermatogenesis DNMT3 |
| 通讯作者 | Hennig, W (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, MPG Guest Lab, DAAD Lab, Shanghai 200031, Peoples R China.,whennig@gmx.de |
| 英文摘要 | It is controversial whether DNA methylation plays a functional role in Drosophila. We have studied testis DNA of Drosophila melanogaster Meigen, 1830 with antisera against 5-methylcytosine (5mC) and found no evidence for the presence of significant amounts of 5mC. Reactions occur only with I of 3 5mC antisera, but they are restricted to nuclear regions without detectable amounts of DNA. The antisera apparently cross-react with other nuclear components. If the murine de novo DNA methyltransferases, DNMT3A and DNMT3B, are expressed under the control of the spermatocyte-specific beta 2-tubulin promoter in testes, DNA methylation is not increased and no effects on the fertility of the fly are seen. DNA methylation has, therefore, no functional relevance in the male germ line of Drosophila. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | CYTOSINE-5 METHYLTRANSFERASES ; Y-CHROMOSOME ; DE-NOVO ; METHYLATION ; MELANOGASTER ; SEQUENCES ; SPERMATOGENESIS ; IDENTIFICATION ; EXPRESSION ; PROTEINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262711600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1373]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Weyrich, A,Tang, XJ,Xu, GL,et al. Mammalian DNMTs in the male germ line DNA of Drosophila[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,2008,86(5):380-385. |
| APA | Weyrich, A,Tang, XJ,Xu, GL,Schrattenholz, A,Hunzinger, C,&Hennig, W.(2008).Mammalian DNMTs in the male germ line DNA of Drosophila.BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,86(5),380-385. |
| MLA | Weyrich, A,et al."Mammalian DNMTs in the male germ line DNA of Drosophila".BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 86.5(2008):380-385. |
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