Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma
文献类型：期刊论文
| 作者 | Mo, W; Zhang, L; Yang, GH; Zhai, JW; Hu, ZH; Chen, YL; Chen, X; Hui, LJ; Huang, RM; Hu, GX |
| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2008 |
| 卷号 | 31期号:5页码:695-707 |
| 通讯作者 | Hu, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,gxhu@sibs.ac.cn |
| 英文摘要 | Signal transducers and activators of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-gamma (IFN-gamma) stimulation. Phosphorylated STAT1 translocates into nucleus to initiate the transcription of IFN-gamma target genes that are important in mediating antiviral, anti proliferative, and immune response. The inactivation of STAT1 is mainly accomplished via tyrosine dephosphorylation by the nuclear isoform of T cell protein tyrosine phosphatase (TC45) in nucleus. Here we show that beta-arrestin1 directly interacts with STAT1 in nucleus after IFN-gamma treatment and accelerates STAT1 tyrosine dephosphorylation by recruiting TC45. Consequently, beta-arrestin1 negatively regulates STAT1 transcription activity as well as the IFN-gamma-induced gene transcription. Application of beta-arrestin1 siRNA significantly enhances IFN-gamma-induced antiviral response in vesicular stomatitis virus (VSV)-infected cells. Our results reveal that nuclear beta-arrestin1, acting as a scaffold for the dephosphorylation of STAT1, is an essential negative regulator of IFN-gamma signaling and participates in the IFN-y-induced cellular antiviral response. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | PROTEIN-TYROSINE-PHOSPHATASE ; INTERFERON-GAMMA ; TRANSCRIPTION FACTOR ; BETA-ARRESTINS ; GENE ACTIVATION ; RECEPTOR ; JAK ; VIRUS ; PHOSPHORYLATION ; REQUIRES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259113800011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1376]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mo, W,Zhang, L,Yang, GH,et al. Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma[J]. MOLECULAR CELL,2008,31(5):695-707. |
| APA | Mo, W.,Zhang, L.,Yang, GH.,Zhai, JW.,Hu, ZH.,...&Hu, GX.(2008).Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma.MOLECULAR CELL,31(5),695-707. |
| MLA | Mo, W,et al."Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma".MOLECULAR CELL 31.5(2008):695-707. |
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