mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern
文献类型：期刊论文
| 作者 | Wang, YF; Shao, XX; Li, M; Wang, SM; Chi, CW; Wang, CG |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2008 |
| 卷号 | 40期号:5页码:391-396 |
| 关键词 | conotoxin Conus marmoreus disulfide connectivity mr1e |
| 通讯作者 | Wang, CG (reprint author), Tongji Univ, Inst Prot Res, Shanghai 200092, Peoples R China.,chunguangwang@mail.tongji.edu.cn |
| 英文摘要 | Conotoxins are well known for their highly variable structures and functions. Here we report the identification of a novel conotoxin named mr1e from Conus marmoreus. mr1e is composed of 11 amino acid residues cross-linked by two disulfide bonds (CCHSSWCKHLC). The spacing of intercysteine loops in mr1e is exactly the same as that in alpha 4/3 conotoxins. However, the native mr1e peptide co-eluted on reverse-phase HPLC with the regioselectively synthesized ribbon disulfide linkage isomer (C-1-C-4, C-2-C-3) but not the globular linkage isomer (C-1-C-3, C-2-C-4). Although this peptide has the same disulfide connectivity as the chi-conotoxins, their sequences do not share significant homology. Thus, mr1e could be defined as a novel conotoxin family. By intracranial injection into mice, mr1e showed an excitatory effect. The characterization of mr1e certainly enriches our understanding of conotoxins, and also opens an avenue for further structural and functional investigation. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ACETYLCHOLINE-RECEPTOR ANTAGONISTS ; ALPHA-CONOTOXINS ; PEPTIDES ; VENOM ; CONOPEPTIDES ; SUPERFAMILY ; TRANSPORTER ; SUBTYPES ; FAMILY ; TOOLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255930600004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1377]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, YF,Shao, XX,Li, M,et al. mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2008,40(5):391-396. |
| APA | Wang, YF,Shao, XX,Li, M,Wang, SM,Chi, CW,&Wang, CG.(2008).mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,40(5),391-396. |
| MLA | Wang, YF,et al."mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 40.5(2008):391-396. |
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