Two different groups of signal sequence in M-superfamily conotoxins
文献类型：期刊论文
| 作者 | Wang, Q; Jiang, H; Han, YH; Yuan, DD; Chi, CW |
| 刊名 | TOXICON
 |
| 出版日期 | 2008 |
| 卷号 | 51期号:5页码:813-822 |
| 关键词 | conotoxin M-superfamily cDNA cloning signal peptide sequence alignment phylogenetic analysis |
| 通讯作者 | Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,chi@sunm.shcnc.ac.cn |
| 英文摘要 | M-superfamily conotoxins can be divided into four branches (M-1, M-2, M-3 and M-4) according to the number of amino acid residues in the third Cys loop. In general, it is widely accepted that the conotoxin signal peptides of each superfamily are strictly conserved. Recently, we cloned six cDNAs of novel M-superfamily conotoxins from Conus leopardus, Conus marmoreus and Conus quercinus, belonging to either M-1 or M-3 branch. These conotoxins, judging from the putative peptide sequences deducted from cDNAs, are rich in acidic residues and share highly conserved signal and pro-peptide region. However, they are quite different from the reported conotoxins of M-2 and M-4 branches even in their signal peptides, which in general are considered highly conserved for each superfamily of conotoxins. The signal sequences of M-1 and M-3 conotoxins composed of 24 residues start with MLKMGVVL-, while those of M-2 and M-4 conotoxins composed of 25 residues start with MMSKLGVL-. It is another example that different types of signal peptides can exist within a superfamily besides the I-conotoxin superfamily. In addition to the different disulfide connectivity of M-1 conotoxins from that of M-4 or M-2 conotoxins, the sequence alignment, preferential Cys codon usage and phylogenctic tree analysis suggest that M-1 and M-3 conotoxins have much closer relationship, being different from the conotoxins of other two branches (M-4 and M-2) of M-superfamily. (c) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | DISULFIDE LINKAGE ; VENOM PEPTIDES ; CONUS VENOMS ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255150400010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1384]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Q,Jiang, H,Han, YH,et al. Two different groups of signal sequence in M-superfamily conotoxins[J]. TOXICON,2008,51(5):813-822. |
| APA | Wang, Q,Jiang, H,Han, YH,Yuan, DD,&Chi, CW.(2008).Two different groups of signal sequence in M-superfamily conotoxins.TOXICON,51(5),813-822. |
| MLA | Wang, Q,et al."Two different groups of signal sequence in M-superfamily conotoxins".TOXICON 51.5(2008):813-822. |
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