First intron of nestin gene regulates its expression during C2C12 myoblast differentiation
文献类型：期刊论文
| 作者 | Zhong, H; Jin, ZG; Chen, YF; Zhang, T; Bian, W; Cui, X; Jing, NH |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2008 |
| 卷号 | 40期号:6页码:526-532 |
| 关键词 | nestin C2C12 myoblast muscle-specific enhancer MyoD |
| 通讯作者 | Cui, X (reprint author), Shandong Univ, Sch Med, Jinan 250012, Peoples R China.,cuixing77@sdu.edu.cn ; njing@sibs.ac.cn |
| 英文摘要 | Nestin is an intermediate filament protein expressed in neural progenitor cells and in developing skeletal muscle. Nestin has been widely used as a neural progenitor cell marker. It is well established that the specific expression of the nestin gene in neural progenitor cells is conferred by the neural-specific enhancer located in the second intron of the nestin gene. However, the transcriptional mechanism of nestin expression in developing muscle is still unclear. In this study, we identified a muscle cell-specific enhancer in the first intron of mouse nestin gene in mouse myoblast C2C12 cells. We localized the core enhancer activity to the 291-661 region of the first intron, and showed that the two E-boxes in the core enhancer region were important for enhancer activity in differentiating C2C12 cells. We also showed that MyoD protein was involved in the regulation of nestin expression in the myogenic differentiation of C2C12 cells. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | MUSCLE DEVELOPMENT ; BINDING-SITE ; STEM-CELLS ; PROTEIN ; MYOD ; SEQUENCE ; ENHANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256851700009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1388]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhong, H,Jin, ZG,Chen, YF,et al. First intron of nestin gene regulates its expression during C2C12 myoblast differentiation[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2008,40(6):526-532. |
| APA | Zhong, H.,Jin, ZG.,Chen, YF.,Zhang, T.,Bian, W.,...&Jing, NH.(2008).First intron of nestin gene regulates its expression during C2C12 myoblast differentiation.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,40(6),526-532. |
| MLA | Zhong, H,et al."First intron of nestin gene regulates its expression during C2C12 myoblast differentiation".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 40.6(2008):526-532. |
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