Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence
文献类型：期刊论文
| 作者 | Peng, C; Liu, L; Shao, XX; Chi, CW; Wang, CG |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:6页码:985-991 |
| 关键词 | conotoxin V-superfamily cysteine framework diversity |
| 通讯作者 | Wang, CG (reprint author), Tongji Univ, Inst Prot Res, 1239 Siping Rd, Shanghai 200092, Peoples R China.,chunguangwang@mail.tongji.edu.cn |
| 英文摘要 | Cone snails are predatory gastropod mollusks distributed in all tropical marine habitats with a highly sophisticated defense strategy using small peptides in their venoms. Here, we report the discovery and initial characterization of the V-superfamily conotoxins. A novel conotoxin vi15a was purified from the venom of a worm-hunting species Conus virgo. The sequence of vi15a was determined to have a unique arrangement of cysteine residues (C-C-CC-C-C-C-C), which defines the new V-superfamily conotoxins. The cDNA of vi15a was cloned with RACE method. Its unique signal peptide sequence led to the cloning of another V-superfamily conotoxin, Vt15.1, from Conus vitulinus. These results, as well as the existence of Lt15.1 from Conus litteratus and ca15a from Conus caracteristicus with the same cysteine pattern, suggest that V-superfamily might be a large and diverse group of peptides widely distributed in different Conus species. Like other eight Cys-containing toxins, V-superfamily conotoxins might also adopt an "ICK+1" disulfide bond connectivity. The identification of this novel class of conotoxins will certainly improve our understanding of the structure diversity of disulfide rich toxins. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | CALCIUM-CHANNEL ANTAGONIST ; FUNNEL-WEB SPIDER ; D-AMINO-ACID ; CONUS PEPTIDES ; SODIUM-CHANNEL ; VENOM PEPTIDES ; SUPERFAMILY ; DISCOVERY ; THERAPEUTICS ; CONOPEPTIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256518700014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1397]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Peng, C,Liu, L,Shao, XX,et al. Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence[J]. PEPTIDES,2008,29(6):985-991. |
| APA | Peng, C,Liu, L,Shao, XX,Chi, CW,&Wang, CG.(2008).Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence.PEPTIDES,29(6),985-991. |
| MLA | Peng, C,et al."Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence".PEPTIDES 29.6(2008):985-991. |
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