Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor
文献类型：期刊论文
| 作者 | Jiang, LC; Yao, MH; Shi, J; Shen, P; Niu, G; Fei, J |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 86期号:6页码:1209-1216 |
| 关键词 | RE-1 silencing transcription factor (REST) Ying Yang 1 (YY1) functional binding site mouse REST promoter |
| 通讯作者 | Niu, G (reprint author), Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China.,gniu@sibs.ac.cn |
| 英文摘要 | The RE-1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity. However, the mechanism of REST gene transcription regulation is still an open question. Here, by combining bioinformatics analysis and experimental studies, we report that the transcription factor Yin Yang 1 (YY1) bound to a conserved YY1 binding site in the promoter of the mouse REST gene and positively regulated activity of this promoter in SH-SY5Y cells. Furthermore, analysis of microarray data revealed a significant correlation between the expression of YY1 and REST genes. Overall, this study suggests that YY1 directly regulates expression of the REST gene. (C) 2007 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | SERUM RESPONSE FACTOR ; FACTOR-BINDING SITES ; NEURAL STEM-CELLS ; FACTOR YY1 ; GENE-EXPRESSION ; TARGET GENES ; IN-VIVO ; PROTEIN ; NEURONS ; REPRESSOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255543700003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1399]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, LC,Yao, MH,Shi, J,et al. Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(6):1209-1216. |
| APA | Jiang, LC,Yao, MH,Shi, J,Shen, P,Niu, G,&Fei, J.(2008).Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor.JOURNAL OF NEUROSCIENCE RESEARCH,86(6),1209-1216. |
| MLA | Jiang, LC,et al."Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor".JOURNAL OF NEUROSCIENCE RESEARCH 86.6(2008):1209-1216. |
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