Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction
文献类型：期刊论文
| 作者 | Gan, XQ; Wang, JY; Xi, Y; Wu, ZL; Li, YP; Li, L |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 180期号:6页码:1087-1100 |
| 通讯作者 | Li, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,lli@sibs.ac.cn |
| 英文摘要 | In canonical Wnt signaling, Dishevelled (Dvl) is a critical cytoplasmic regulator that releases beta-catenin from degradation. Here, we find that Dvl and c-Jun form a complex with beta-catenin-T-cell factor 4 ( TCF-4) on the promoter of Wnt target genes and regulate gene transcription. The complex forms via two interactions of nuclear Dvl with c-Jun and beta-catenin, respectively, both of which bind to TCF. Disrupting the interaction of Dvl with either c-Jun or beta-catenin suppresses canonical Wnt signaling stimulated transcription, and the reduction of Dvl diminished beta-catenin-TCF-4 association on Wnt target gene promoters in vivo. Expression of a TCF-Dvl fusion protein largely rescued the c-Jun knockdown Wnt signaling deficiency in mammalian cells and zebrafish. Thus, we confirm that c-Jun functions in canonical Wnt signaling and show that c-Jun functions as a scaffold in the beta-catenin TCFs transcription complex bridging Dvl to TCF. Our results reveal a mechanism by which nuclear Dvl cooperates with c-Jun to regulate gene transcription stimulated by the canonical Wnt signaling pathway. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | WNT SIGNALING PATHWAY ; TRANSCRIPTIONAL REPRESSORS ; MOUSE DEVELOPMENT ; BINDING PROTEIN ; ZEBRAFISH ; TARGET ; ACTIVATION ; GROUCHO ; DISEASE ; LEF-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254295400006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1400]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gan, XQ,Wang, JY,Xi, Y,et al. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction[J]. JOURNAL OF CELL BIOLOGY,2008,180(6):1087-1100. |
| APA | Gan, XQ,Wang, JY,Xi, Y,Wu, ZL,Li, YP,&Li, L.(2008).Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.JOURNAL OF CELL BIOLOGY,180(6),1087-1100. |
| MLA | Gan, XQ,et al."Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction".JOURNAL OF CELL BIOLOGY 180.6(2008):1087-1100. |
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