Quality control of the proteins associated with neurodegenerative diseases
文献类型：期刊论文
| 作者 | Gao, XC; Hu, HY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2008 |
| 卷号 | 40期号:7页码:612-618 |
| 关键词 | quality control protein misfolding molecular chaperones ubiquitin-proteasome system neurodegenerative disease |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | Most neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease and other polyglutamine diseases are associated with degeneration and death of specific neuronal populations due to misfolding or aggregation of certain proteins. These aggregates often contain ubiquitin that is the signal for proteolysis by the ubiquitin-proteasome system, and chaperone proteins that are involved in the assistance of protein folding. Here we review the role of protein quality control systems in the pathogenesis of neurodegenerative diseases, and aim to learn more from the cooperation between molecular chaperones and ubiquitin-proteasome system responding to cellular protein aggregates, in order to find molecular targets for therapeutic intervention. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | UBIQUITIN-PROTEASOME SYSTEM ; MOLECULAR CHAPERONES ; PARKINSONS-DISEASE ; POLYGLUTAMINE DISEASE ; INCLUSION FORMATION ; LEWY BODIES ; CELL-DEATH ; AGGREGATION ; HSP40 ; DEGRADATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257728300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1402]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gao, XC,Hu, HY. Quality control of the proteins associated with neurodegenerative diseases[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2008,40(7):612-618. |
| APA | Gao, XC,&Hu, HY.(2008).Quality control of the proteins associated with neurodegenerative diseases.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,40(7),612-618. |
| MLA | Gao, XC,et al."Quality control of the proteins associated with neurodegenerative diseases".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 40.7(2008):612-618. |
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