Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo
文献类型：期刊论文
| 作者 | Li, SW; Lou, X; Wang, JH; Liu, B; Ma, LP; Su, ZP; Ding, XY |
| 刊名 | DIFFERENTIATION
 |
| 出版日期 | 2008 |
| 卷号 | 76期号:8页码:897-907 |
| 关键词 | retinoids retinoic acid Wnt signaling beta-catenin Xenopus dorsal development |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.,xyding@sunm.shcnc.ac.cn |
| 英文摘要 | Vitamin A derivatives (retinoids) are actively involved during vertebrate embryogenesis. However, exogenous retinoids have also long been known as potent teratogens. The defects caused by retinoid treatment are complex. Here, we provided evidence that RAR-mediated retinoid signaling can repress Xenopus blastula Wnt signaling and impair dorsal development. Exogenous retinoic acid (RA) could antagonize the dorsalizing effects of lithium chloride-mediated Wnt activation in blastula embryos. The Wnt-responsive reporter gene transgenesis and luciferase assay showed that excess RA can repress the Wnt signaling in blastula embryos. In addition, the downstream target genes of the Wnt signaling that direct embryonic dorsal development, were also down-regulated in the RA-treated embryos. Mechanically, RA did not interfere with the stability of beta-catenin, but promoted its nuclear accumulation. The inverse agonist of retinoic acid receptors (RAR) rescued the Wnt signaling repression by RA and relieved the RA-induced nuclear accumulation of beta-catenin. Our results explain one of the reasons for the complicated teratogenic effects of retinoids and shed light on the endogenous way of interactions between two developmentally important signaling pathways. |
| 学科主题 | Cell Biology; Developmental Biology |
| 类目[WOS] | Cell Biology ; Developmental Biology |
| 关键词[WOS] | NODAL-RELATED GENES ; BETA-CATENIN ; CORTICAL ROTATION ; ACID RECEPTOR ; AXIS SPECIFICATION ; NUCLEAR RECEPTORS ; NEURAL INDUCTION ; MOLECULAR-MECHANISM ; SPEMANNS ORGANIZER ; ACTIVE REPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259360300006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1408]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, SW,Lou, X,Wang, JH,et al. Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo[J]. DIFFERENTIATION,2008,76(8):897-907. |
| APA | Li, SW.,Lou, X.,Wang, JH.,Liu, B.,Ma, LP.,...&Ding, XY.(2008).Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo.DIFFERENTIATION,76(8),897-907. |
| MLA | Li, SW,et al."Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo".DIFFERENTIATION 76.8(2008):897-907. |
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