An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells
文献类型：期刊论文
| 作者 | Yu, MC; Su, LL; Zou, L; Liu, Y; Wu, N; Kong, L; Zhuang, ZH; Sun, L; Liu, HP; Hu, JH |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 9期号:8页码:898-907 |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn ; gebaoxue@sibs.ac.cn |
| 英文摘要 | The inhibitory signaling of natural killer (NK) cells is crucial in the regulation of innate immune responses. Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream' inhibitory signaling. Consequently, the cytotoxicity of NK cells was higher in beta-arrestin 2-deficient mice but was inhibited in beta-arrestin 2-transgenic mice. Moreover, beta-arrestin 2-deficient mice were less susceptible than wild-type mice to mouse cytomegalovirus infection, an effect that was abolished by depletion of NK cells. Our findings identify a previously unknown mechanism by which the inhibitory signaling in NK cells is regulated. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | MURINE CYTOMEGALOVIRUS-INFECTION ; MICROTUBULE-ORGANIZING CENTER ; NK CELLS ; TYROSINE PHOSPHATASES ; DOWN-REGULATION ; IMMUNE SYNAPSE ; BETA-ARRESTINS ; PIVOTAL ROLE ; HLA-C ; RECEPTORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257780700013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1416]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yu, MC,Su, LL,Zou, L,et al. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells[J]. NATURE IMMUNOLOGY,2008,9(8):898-907. |
| APA | Yu, MC.,Su, LL.,Zou, L.,Liu, Y.,Wu, N.,...&Ge, BX.(2008).An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.NATURE IMMUNOLOGY,9(8),898-907. |
| MLA | Yu, MC,et al."An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells".NATURE IMMUNOLOGY 9.8(2008):898-907. |
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