Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus
文献类型：期刊论文
| 作者 | Liu, L; Wu, XC; Yuan, DD; Chi, CW; Wang, CG |
| 刊名 | TOXICON
 |
| 出版日期 | 2008 |
| 卷号 | 51期号:8页码:1331-1337 |
| 关键词 | S-superfamily conotoxin sequence diversity cysteine framework CDNA cloning signal peptide |
| 通讯作者 | Wang, CG (reprint author), Tongji Univ, Inst Prot Res, 1239 Siping Rd, Shanghai 200092, Peoples R China.,chunguangwang@mail.tongji.edu.cn |
| 英文摘要 | Conotoxins have been classified into several different superfamilies based on the highly conserved signal peptide sequences of their precursors. However, little is known about the five disulfide bonds containing S-superfamily conotoxins. Only two S-superfamily conotoxins have been identified but their cDNAs are not reported. In this work, we identified a novel S-superfamily conotoxin ca8a from vermivorous Conus caracteristicus. Its sequence shares no homology with those of two other previously reported toxins of the same superfamily, but they have the same cysteine framework, in particular the CX3CXC-CXC-CXCXC pattern at the C-terminal part. This implies that these toxins might have the same spatial scaffold, but different local conformation or residue side chains may be the cause of their different biological functions. Furthermore, the cDNA of ca8a was cloned with the RACE method. ca8a has a signal peptide sequence different from those of other conotoxins. This gives a defining feature of S-superfamily conotoxins and led to the cloning of more S-superfamily conotoxins from cone snails of different prey types, which indicates that S-superfamily conotoxins widely exist. These results will certainly enrich our understanding of the highly diversified S-superfamily conotoxins. (c) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | DISULFIDE LINKAGE ; ION-CHANNEL ; PEPTIDES ; SUBTYPES ; VENOMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257645200002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1418]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, L,Wu, XC,Yuan, DD,et al. Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus[J]. TOXICON,2008,51(8):1331-1337. |
| APA | Liu, L,Wu, XC,Yuan, DD,Chi, CW,&Wang, CG.(2008).Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus.TOXICON,51(8),1331-1337. |
| MLA | Liu, L,et al."Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus".TOXICON 51.8(2008):1331-1337. |
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