Role of Toll-like receptors in regulatory functions of T and B cells
文献类型：期刊论文
| 作者 | Chang, ZL |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2008 |
| 卷号 | 53期号:8页码:1121-1127 |
| 关键词 | TLRs T cells B cells therapeutic potential |
| 通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,chang_zong_liang@sibs.ac.cn |
| 英文摘要 | Pathogens can find their ways to most sites in the host. Pathogen sensors, such as Toll-like receptors (TLRs), must be equally and broadly distributed on immune cells to combat them through innate and adaptive immunity. Most classes of TLRs are found in innate immune cells to obtain an immediate response against pathogens, but recent studies indicate that a number of TLRs are wildly expressed in T and B cells, suggesting TLRs also directly regulate adaptive immune responses. Due to the rapid increase of new information on the multiple roles of TLRs, in this paper we aim to review several main properties of TLRs and their direct role in T and B cells. This review consists of 6 parts: (i) Characteristics of Toll-like receptors (TLRs) and signaling; (ii) signalling pathways of TLRs; (iii) TLR expressions on human leukocytes; (iv) TLR expressions and functions in the Thl, CD4+CD45RO+ memory T cells and regulatory/suppressor T as well as B cell populations; (v) therapeutic potential of TLR agonists; (Vi) discussion and perspective. The latest findings and potential therapeutic applications are discussed. There is growing evidence supporting the concept that TLR activation contributes not only to innate immunity but also to adaptive immunity, including direct regulation of both T and B lymphocytes by TLRs. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | NONHUMAN-PRIMATES ; LIGAND FLAGELLIN ; INNATE IMMUNITY ; CUTTING EDGE ; EXPRESSION ; RESPONSES ; AGONISTS ; LEUKOCYTES ; DROSOPHILA ; MAGNITUDE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254999100001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1421]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chang, ZL. Role of Toll-like receptors in regulatory functions of T and B cells[J]. CHINESE SCIENCE BULLETIN,2008,53(8):1121-1127. |
| APA | Chang, ZL.(2008).Role of Toll-like receptors in regulatory functions of T and B cells.CHINESE SCIENCE BULLETIN,53(8),1121-1127. |
| MLA | Chang, ZL."Role of Toll-like receptors in regulatory functions of T and B cells".CHINESE SCIENCE BULLETIN 53.8(2008):1121-1127. |
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